SMPD1 and ASAH1

Number of citations of the paper that reports this interaction (PubMedID 12815059)
35

Data Source:
HPRD (in vitro)

		SMPD1	ASAH1
Description		sphingomyelin phosphodiesterase 1	N-acylsphingosine amidohydrolase 1
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GO Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Lysosome Early Endosome Endoplasmic Reticulum Lysosomal Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides N-acylsphingosine Amidohydrolase Activity Ceramidase Activity
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Ceramide Biosynthetic Process	Glycosphingolipid Metabolic Process Keratinocyte Differentiation Neutrophil Degranulation Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Ceramide Catabolic Process Regulation Of Steroid Biosynthetic Process Cellular Response To Tumor Necrosis Factor
Pathways		Glycosphingolipid metabolism	Glycosphingolipid metabolism Neutrophil degranulation
Drugs		Amlodipine Chlorpromazine Desipramine
Diseases		Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B	Farber lipogranulomatosis; Farber disease
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Neurological blood protein biomarker levels ( 31320639)	Atrial fibrillation ( 28416818 30061737 29892015) Night sleep phenotypes ( 27126917) Obesity ( 21552555)
Interacting Genes		6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2	6 interacting genes: CAMK1D HSPB2 SETDB1 SMPD1 SRPK1 TSC22D1
Entrez ID		6609	427
HPRD ID		06353	01969
Ensembl ID		ENSG00000166311	ENSG00000104763
Uniprot IDs		E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0	A8K0B6 Q13510 Q53H01
PDB IDs		5I81 5I85 5I8R 5JG8	5U7Z 6MHM
Enriched GO Terms of Interacting Partners?
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