TNPO2 and NME1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TNPO2	NME1
Description		transportin 2	NME/NM23 nucleoside diphosphate kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cell Nucleus Cytoplasm Mitochondrial Outer Membrane Centrosome Cytosol Intermediate Filament Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Ran GTPase Binding Nuclear Import Signal Receptor Activity	Magnesium Ion Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding RNA Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding
	Biological Process	Protein Import Into Nucleus	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Metabolic Process Endocytosis Lactation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Hippocampus Development Response To Testosterone Cellular Response To Drug Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs			Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate Fudp Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate 3'-Azido-3'-Deoxythymidine-5'-Diphosphate Copper
Diseases
GWAS		Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)	Bipolar disorder ( 31043756) Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: A1CF APIP C1orf94 CAMK2D CRYAB ELAVL1 EXOC5 KLHL2 NME1 NUP98 NXF1 PIK3CD PNMA5 RAN RPL4 TCL1B TERF1 TRMT1	29 interacting genes: APEX1 AURKA CCND3 FBXO24 FXR2 GORASP2 ITGB1 KSR1 MIF NIF3L1 NME2 NME3 NME4 NTAQ1 PID1 POLR1C PRUNE1 PTEN RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2
Entrez ID		30000	4830
HPRD ID		04301	01131
Ensembl ID		ENSG00000105576	ENSG00000239672
Uniprot IDs		A0A024R7F7 O14787 Q05D48 Q4LE60	A0A384MTW7 P15531
PDB IDs			1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4
Enriched GO Terms of Interacting Partners?
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