TNPO2 and APIP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TNPO2	APIP
Description		transportin 2	APAF1 interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Ran GTPase Binding Nuclear Import Signal Receptor Activity	Protein Binding Zinc Ion Binding Identical Protein Binding Methylthioribulose 1-phosphate Dehydratase Activity
	Biological Process	Protein Import Into Nucleus	Apoptotic Process L-methionine Salvage From S-adenosylmethionine L-methionine Salvage From Methylthioadenosine Negative Regulation Of Apoptotic Process Protein Homotetramerization Pyroptosis Regulation Of ERK1 And ERK2 Cascade
Pathways			Formation of apoptosome Methionine salvage pathway Regulation of the apoptosome activity
Drugs
Diseases
GWAS		Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797) Gamma glutamyl transferase levels ( 29403010) Lung disease severity in cystic fibrosis ( 26417704) Prostate-specific antigen levels ( 28139693) Systemic lupus erythematosus ( 19838195)
Interacting Genes		18 interacting genes: A1CF APIP C1orf94 CAMK2D CRYAB ELAVL1 EXOC5 KLHL2 NME1 NUP98 NXF1 PIK3CD PNMA5 RAN RPL4 TCL1B TERF1 TRMT1	17 interacting genes: APAF1 CFAP206 IMPDH2 LNX1 NIF3L1 NTAQ1 NUDT18 PDZD4 PPP1CC PSMA1 SDCBP SKP1 TNPO2 TSC22D4 VIM VPS25 ZBTB25
Entrez ID		30000	51074
HPRD ID		04301	14725
Ensembl ID		ENSG00000105576	ENSG00000149089
Uniprot IDs		A0A024R7F7 O14787 Q05D48 Q4LE60	Q96GX9
PDB IDs			4M6R
Enriched GO Terms of Interacting Partners?
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