NME1 and KSR1

Number of citations of the paper that reports this interaction (PubMedID 12105213)
50

Data Source:
HPRD (in vitro, in vivo)

		NME1	KSR1
Description		NME/NM23 nucleoside diphosphate kinase 1	kinase suppressor of ras 1
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GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Mitochondrial Outer Membrane Centrosome Cytosol Intermediate Filament Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Ruffle Membrane Protein-containing Complex
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding RNA Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding	Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Protein C-terminus Binding Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding Chaperone Binding Hsp90 Protein Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Metabolic Process Endocytosis Lactation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Hippocampus Development Response To Testosterone Cellular Response To Drug Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	MAPK Cascade Activation Of MAPKKK Activity Ras Protein Signal Transduction CAMP-mediated Signaling Regulation Of Cell Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade
Pathways		Interconversion of nucleotide di- and triphosphates	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs		Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate Fudp Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate 3'-Azido-3'-Deoxythymidine-5'-Diphosphate Copper
Diseases
GWAS		Bipolar disorder ( 31043756) Metabolite levels ( 23823483)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Systemic lupus erythematosus ( 28714469)
Interacting Genes		29 interacting genes: APEX1 AURKA CCND3 FBXO24 FXR2 GORASP2 ITGB1 KSR1 MIF NIF3L1 NME2 NME3 NME4 NTAQ1 PID1 POLR1C PRUNE1 PTEN RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2	10 interacting genes: BRAP EPHB2 MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 UBE2L3 YWHAZ
Entrez ID		4830	8844
HPRD ID		01131	18980
Ensembl ID		ENSG00000239672	ENSG00000141068
Uniprot IDs		A0A384MTW7 P15531	Q8IVT5
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4	5VYK
Enriched GO Terms of Interacting Partners?
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