NME1 and RRAD

Number of citations of the paper that reports this interaction (PubMedID 10611312)
28

Data Source:
HPRD (in vitro, in vivo)

		NME1	RRAD
Description		NME/NM23 nucleoside diphosphate kinase 1	RRAD, Ras related glycolysis inhibitor and calcium channel regulator
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GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Mitochondrial Outer Membrane Centrosome Cytosol Intermediate Filament Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding RNA Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding	GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Metabolic Process Endocytosis Lactation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Hippocampus Development Response To Testosterone Cellular Response To Drug Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	Small GTPase Mediated Signal Transduction Negative Regulation Of High Voltage-gated Calcium Channel Activity
Pathways		Interconversion of nucleotide di- and triphosphates	NGF-stimulated transcription
Drugs		Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate Fudp Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate 3'-Azido-3'-Deoxythymidine-5'-Diphosphate Copper
Diseases
GWAS		Bipolar disorder ( 31043756) Metabolite levels ( 23823483)
Interacting Genes		29 interacting genes: APEX1 AURKA CCND3 FBXO24 FXR2 GORASP2 ITGB1 KSR1 MIF NIF3L1 NME2 NME3 NME4 NTAQ1 PID1 POLR1C PRUNE1 PTEN RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2	14 interacting genes: CALM1 CAMK2G CSNK2A1 CSNK2B EEA1 EGFR MMP14 NME1 PRKACA PRKCA PRKCB STAT3 TPM2 YWHAZ
Entrez ID		4830	6236
HPRD ID		01131	01536
Ensembl ID		ENSG00000239672	ENSG00000166592
Uniprot IDs		A0A384MTW7 P15531	A0A024R6X0 P55042
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4	2DPX 2GJS 3Q72 3Q7P 3Q7Q
Enriched GO Terms of Interacting Partners?
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