HPGDS and ARRDC3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		HPGDS	ARRDC3
Description		hematopoietic prostaglandin D synthase	arrestin domain containing 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Lysosome Endosome Early Endosome Plasma Membrane
	Molecular Function	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Binding Protein Homodimerization Activity	Protein Binding Beta-3 Adrenergic Receptor Binding
	Biological Process	Prostaglandin Metabolic Process Glutathione Metabolic Process Signal Transduction Locomotory Behavior Cyclooxygenase Pathway Glutathione Derivative Biosynthetic Process Negative Regulation Of Male Germ Cell Proliferation	Temperature Homeostasis Negative Regulation Of Heat Generation Skin Development Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Cold-induced Thermogenesis
Pathways		Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Glutathione Vitamin A Tretinoin 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE Tranilast 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Glycerin
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576 29875488) Testicular germ cell tumor ( 28604728 28604732 23666239)	Breast cancer ( 29059683 25038754) Breast cancer (prognosis) ( 23319801) Breast cancer (survival) ( 25526632) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		4 interacting genes: ABHD17A ARRDC3 HK3 MELTF	14 interacting genes: ADRB2 BAG3 DCUN1D1 F2R HPGDS ITCH MAGI2 MORF4L1 OTUB2 PDCD6IP STAM2 TNFAIP3 TRIM42 UBE2E2
Entrez ID		27306	57561
HPRD ID		04001	09810
Ensembl ID		ENSG00000163106	ENSG00000113369
Uniprot IDs		A0A384P5J0 O60760	Q96B67
PDB IDs		1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E	4N7H 4R7V 4R7X
Enriched GO Terms of Interacting Partners?
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