ARRDC3 and DCUN1D1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ARRDC3	DCUN1D1
Description		arrestin domain containing 3	defective in cullin neddylation 1 domain containing 1
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GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Plasma Membrane	Ubiquitin Ligase Complex Nucleoplasm Cytosol
	Molecular Function	Protein Binding Beta-3 Adrenergic Receptor Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Temperature Homeostasis Negative Regulation Of Heat Generation Skin Development Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Cold-induced Thermogenesis	Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation
Pathways			Neddylation
Drugs
Diseases
GWAS		Breast cancer ( 29059683 25038754) Breast cancer (prognosis) ( 23319801) Breast cancer (survival) ( 25526632) Subcutaneous adipose tissue ( 22589738)	Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		14 interacting genes: ADRB2 BAG3 DCUN1D1 F2R HPGDS ITCH MAGI2 MORF4L1 OTUB2 PDCD6IP STAM2 TNFAIP3 TRIM42 UBE2E2	25 interacting genes: ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CUL5 DAZAP2 DVL2 LAPTM5 LZTS2 MAP3K1 NEDD4 RHOA RNF11 SMAD2 TLE5 TP53BP2 TRIM39 TRIM54 UBC UBE2D3 UBE2F UBE2M VPS37B
Entrez ID		57561	54165
HPRD ID		09810	12067
Ensembl ID		ENSG00000113369	ENSG00000043093
Uniprot IDs		Q96B67	B4DM76 C9JVE2 Q96GG9
PDB IDs		4N7H 4R7V 4R7X	3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W
Enriched GO Terms of Interacting Partners?
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