GBA and PSAP

Number of citations of the paper that reports this interaction (PubMedID 7613473)
10

Data Source:
HPRD (in vitro)

		GBA	PSAP
Description		glucosylceramidase beta	prosaposin
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Extrinsic Component Of Membrane Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Aggresome Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Glucosylceramidase Activity Signaling Receptor Binding Scavenger Receptor Binding Protein Binding Hydrolase Activity Glucosyltransferase Activity Steryl-beta-glucosidase Activity	G Protein-coupled Receptor Binding Protease Binding Beta-galactosidase Activity Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Lipid Antigen Binding Protein Homodimerization Activity Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding
	Biological Process	Glucosylceramide Catabolic Process Glycosphingolipid Metabolic Process Autophagy Mitochondrion Organization Lysosome Organization Cholesterol Metabolic Process Cellular Response To Starvation Response To PH Regulation Of Macroautophagy Termination Of Signal Transduction Lipid Glycosylation Neuron Projection Development Negative Regulation Of Protein Complex Assembly Regulation Of TOR Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production Regulation Of Water Loss Via Skin Response To Testosterone Positive Regulation Of Protein Dephosphorylation Cell Death In Response To Oxidative Stress Positive Regulation Of Protein Complex Disassembly Negative Regulation Of MAP Kinase Activity Skin Morphogenesis Response To Estrogen Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Response To Thyroid Hormone Negative Regulation Of Neuron Death Beta-glucoside Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Lipidation Positive Regulation Of Neuronal Action Potential Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process	NK T Cell Differentiation Platelet Degranulation Corneocyte Development Glucosylceramide Metabolic Process Galactosylceramide Catabolic Process Glycosphingolipid Metabolic Process Lipid Transport Intracellular Protein Transport Lysosomal Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Protein Secretion Gene Expression Regulation Of Autophagy Regulation Of Lipid Metabolic Process Antigen Processing And Presentation Cerebellar Purkinje Cell Differentiation Myelination Neutrophil Degranulation Positive Regulation Of MAPK Cascade Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity Micturition Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Inclusion Body Assembly Cellular Response To Organic Substance Cochlea Development Walking Behavior Negative Regulation Of Hydrogen Peroxide-induced Cell Death Cornified Envelope Assembly Lysosomal Protein Catabolic Process Ganglioside GM1 Transport To Membrane
Pathways		Glycosphingolipid metabolism Association of TriC/CCT with target proteins during biosynthesis	Platelet degranulation Glycosphingolipid metabolism Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation
Drugs		scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL	Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Gaucher disease Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)	Krabbe disease; Globoid cell leukodystrophy Metachromatic leukodystrophy (MLD) Gaucher disease
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Dementia with Lewy bodies ( 29263008 31065058) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 30823506) Parkinson's disease ( 22451204 25064009 27182965 24842889 28892059 21738487) Renal function-related traits (BUN) ( 22797727)	Asthma (childhood onset) ( 23829686) Blood protein levels ( 30072576) Seasonality and depression ( 30217971)
Interacting Genes		3 interacting genes: NEDD4 PSAP SNCA	18 interacting genes: BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD ERBB2 GBA MAFF NLGN3 PRAG1 SMAD2 SMAD9 TOMM70 UBE3A USP4 ZBED1
Entrez ID		2629	5660
HPRD ID		06973	01460
Ensembl ID		ENSG00000177628	ENSG00000197746
Uniprot IDs		A0A068F658 B7Z6S9 P04062	A0A024QZQ2 P07602
PDB IDs		1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX 6MOZ 6Q6K 6Q6L 6Q6N	1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O
Enriched GO Terms of Interacting Partners?
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