GBA

Description		glucosylceramidase beta
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Extrinsic Component Of Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Glucosylceramidase Activity Signaling Receptor Binding Scavenger Receptor Binding Protein Binding Hydrolase Activity Glucosyltransferase Activity Steryl-beta-glucosidase Activity
	Biological Process	Glucosylceramide Catabolic Process Glycosphingolipid Metabolic Process Autophagy Mitochondrion Organization Lysosome Organization Cholesterol Metabolic Process Cellular Response To Starvation Response To PH Regulation Of Macroautophagy Termination Of Signal Transduction Lipid Glycosylation Neuron Projection Development Negative Regulation Of Protein Complex Assembly Regulation Of TOR Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production Regulation Of Water Loss Via Skin Response To Testosterone Positive Regulation Of Protein Dephosphorylation Cell Death In Response To Oxidative Stress Positive Regulation Of Protein Complex Disassembly Negative Regulation Of MAP Kinase Activity Skin Morphogenesis Response To Estrogen Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Response To Thyroid Hormone Negative Regulation Of Neuron Death Beta-glucoside Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Lipidation Positive Regulation Of Neuronal Action Potential Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process
Pathways		Glycosphingolipid metabolism Association of TriC/CCT with target proteins during biosynthesis
Drugs		scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Gaucher disease Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Dementia with Lewy bodies ( 29263008 31065058) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 30823506) Parkinson's disease ( 22451204 25064009 27182965 24842889 28892059 21738487) Renal function-related traits (BUN) ( 22797727)
Interacting Genes		3 interacting genes: NEDD4 PSAP SNCA
Entrez ID		2629
HPRD ID		06973
Ensembl ID		ENSG00000177628
Uniprot IDs		A0A068F658 B7Z6S9 P04062
PDB IDs		1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX 6MOZ 6Q6K 6Q6L 6Q6N
Enriched GO Terms of Interacting Partners?
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