TXN2 and RABGEF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TXN2	RABGEF1
Description		thioredoxin 2	RAB guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Cell Nucleolus Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome
	Molecular Function	Protein Binding Peptide-methionine (S)-S-oxide Reductase Activity Protein Disulfide Oxidoreductase Activity Peptide-methionine (R)-S-oxide Reductase Activity Protein-containing Complex Binding	DNA Binding Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Sulfur Amino Acid Catabolic Process Response To Hypoxia Glycerol Ether Metabolic Process Response To Oxidative Stress Response To Hormone Response To Glucose Response To Organic Cyclic Compound Cellular Response To Nutrient Levels Response To Drug Cell Redox Homeostasis Response To Axon Injury Oxidation-reduction Process	Protein Targeting To Membrane Endocytosis
Pathways		Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species	TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Aortic root size ( 21223598) Central corneal thickness ( 29760442)
Interacting Genes		35 interacting genes: AGTRAP ALDOB AP2B1 CCDC114 DCTD FAM9B GPRASP2 KRT18 KRT40 MAGEA11 MAPRE2 MAPRE3 MLH1 MRFAP1L1 MTUS2 PPCDC PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SCYL3 SHARPIN SSNA1 STUB1 SUN2 THAP1 TIFA TRIM21 TRIP6 UCHL5 VIM VPS52 ZBTB14	29 interacting genes: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 DNAJC5 GGA1 GGA2 HRAS KXD1 MON1A MON1B RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		25828	27342
HPRD ID		07161	11477
Ensembl ID		ENSG00000100348	ENSG00000154710
Uniprot IDs		B4DX69 Q99757	A0A024RDL6 A0A0A0MSJ3 A8K3R3 B3KMF1 Q9UJ41
PDB IDs		1UVZ 1W4V 1W89	1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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