RABGEF1 and TRIM15

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RABGEF1	TRIM15
Description		RAB guanine nucleotide exchange factor 1	tripartite motif containing 15
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding	Protein Binding Zinc Ion Binding
	Biological Process	Protein Targeting To Membrane Endocytosis	Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 29760442)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Neurociticism ( 29500382) Neuroticism ( 29255261)
Interacting Genes		29 interacting genes: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 DNAJC5 GGA1 GGA2 HRAS KXD1 MON1A MON1B RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C	36 interacting genes: ACD ACTB AXIN1 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2U VASP VCL VIM
Entrez ID		27342	89870
HPRD ID		11477	15551
Ensembl ID		ENSG00000154710	ENSG00000204610
Uniprot IDs		A0A024RDL6 A0A0A0MSJ3 A8K3R3 B3KMF1 Q9UJ41	Q5SRL0 Q9C019
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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