FBXL2 and SKP1

Number of citations of the paper that reports this interaction (PubMedID 10531037)
122

Data Source:
HPRD (in vivo, in vitro)

		FBXL2	SKP1
Description		F-box and leucine rich repeat protein 2	S-phase kinase associated protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Cell Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex PcG Protein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modulation By Host Of Viral RNA Genome Replication	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Iron Ion Homeostasis SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Post-translational Protein Modification T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Maintenance Of Protein Location In Nucleus Interleukin-1-mediated Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition
Pathways			Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK - noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs			1-naphthaleneacetic acid (2S)-2-(1H-indol-3-yl)hexanoic acid (2S)-2-(1H-indol-3-yl)pentanoic acid (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid 1H-INDOL-3-YLACETIC ACID
Diseases
GWAS		Heel bone mineral density ( 30598549) Rostral anterior cingulate cortex volume ( 31530798)	Systemic lupus erythematosus ( 27399966 26502338)
Interacting Genes		12 interacting genes: APP AURKB CCND2 CDC34 COL7A1 ITPR3 NLRP3 PIK3R2 SKP1 UBE2D1 UBE2D3 UBE2G1	68 interacting genes: ANKRD36BP1 APIP BTRC CACYBP CAND1 CCNA2 CDCA3 CDK2 CDK4 CDK9 CDKN1A CDKN1B CENPE CUL1 CUL7 DDX19B FBH1 FBXL2 FBXL3 FBXL4 FBXL5 FBXL6 FBXL8 FBXO15 FBXO16 FBXO17 FBXO2 FBXO25 FBXO3 FBXO32 FBXO34 FBXO4 FBXO44 FBXO5 FBXO6 FBXO7 FBXO8 FBXO9 FBXW2 FBXW5 FBXW7 FBXW8 GHR GLMN GPS1 HSP90AA1 KCTD9 LMO2 MED21 MYC NFKBIA NFKBIB NFKBIE NUDT9P1 PPARGC1A PPP1CA PTEN RBX1 SEC23B SKP2 SUGT1 TBL1X TERF1 TRRAP TTC21A TTC9C UBE2D1 UHRF2
Entrez ID		25827	6500
HPRD ID		05736	03255
Ensembl ID		ENSG00000153558	ENSG00000113558
Uniprot IDs		Q9UKC9	P63208
PDB IDs		6O60	1FQV 1FS1 1FS2 1LDK 1P22 2ASS 2AST 2E31 2E32 2OVP 2OVQ 2OVR 3L2O 3WSO 4I6J 5IBK 5JH5 5K35 5V4B 5VZT 5VZU 5XYL 6BVA 6BYH 6C16 6M90 6M91 6M92 6M93 6M94 6O60
Enriched GO Terms of Interacting Partners?
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