SKP1 and CDKN1A

Number of citations of the paper that reports this interaction (PubMedID 25241761)
10

Data Source:
BioGRID (imaging technique, pull down)

		SKP1	CDKN1A
Description		S-phase kinase associated protein 1	cyclin dependent kinase inhibitor 1A
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex PcG Protein Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body Protein-containing Complex Perinuclear Region Of Cytoplasm PCNA-p21 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Cyclin-dependent Protein Kinase Activating Kinase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Iron Ion Homeostasis SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Post-translational Protein Modification T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Maintenance Of Protein Location In Nucleus Interleukin-1-mediated Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Import Into Nucleus Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Heart Development Negative Regulation Of Cell Proliferation Response To Toxic Substance Response To X-ray Response To Organonitrogen Compound Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Animal Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Cellular Response To Amino Acid Starvation Cellular Response To Heat Tissue Regeneration Negative Regulation Of Phosphorylation Response To Drug Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Arsenic-containing Substance Positive Regulation Of Fibroblast Proliferation Protein Stabilization Response To Corticosterone Response To Hyperoxia Intestinal Epithelial Cell Maturation Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Mitotic Cell Cycle Arrest Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK - noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes
Drugs		1-naphthaleneacetic acid (2S)-2-(1H-indol-3-yl)hexanoic acid (2S)-2-(1H-indol-3-yl)pentanoic acid (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid 1H-INDOL-3-YLACETIC ACID	Arsenic trioxide
Diseases			Cervical cancer
GWAS		Systemic lupus erythematosus ( 27399966 26502338)	Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 22634755 30529582) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Ischemic stroke ( 29531354) Left ventricular fractional shortening ( 28394258) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 30679814 27577874 31251759 25035420 31217584 21076409 27659466) Triglycerides ( 27036123)
Interacting Genes		68 interacting genes: ANKRD36BP1 APIP BTRC CACYBP CAND1 CCNA2 CDCA3 CDK2 CDK4 CDK9 CDKN1A CDKN1B CENPE CUL1 CUL7 DDX19B FBH1 FBXL2 FBXL3 FBXL4 FBXL5 FBXL6 FBXL8 FBXO15 FBXO16 FBXO17 FBXO2 FBXO25 FBXO3 FBXO32 FBXO34 FBXO4 FBXO44 FBXO5 FBXO6 FBXO7 FBXO8 FBXO9 FBXW2 FBXW5 FBXW7 FBXW8 GHR GLMN GPS1 HSP90AA1 KCTD9 LMO2 MED21 MYC NFKBIA NFKBIB NFKBIE NUDT9P1 PPARGC1A PPP1CA PTEN RBX1 SEC23B SKP2 SUGT1 TBL1X TERF1 TRRAP TTC21A TTC9C UBE2D1 UHRF2	188 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOXD8 HPD IKBKG IKZF3 ING5 INPP5K KLHL23 KMT2B KRT31 LATS2 LRIF1 LRR1 MAP3K5 MAPK8 MCM10 MED31 MSH2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 PKM POLD2 PRKACA PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RB1 RBBP4 RBM48 RNF126 RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SDF4 SET SETDB1 SIPA1 SKP1 SKP2 SLC25A11 SP110 SPRED1 STAT3 STUB1 SUMO3 TAF5L TCF4 TEX11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TP53 TRAF1 TRIM3 TRIM54 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USP11 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431
Entrez ID		6500	1026
HPRD ID		03255	00298
Ensembl ID		ENSG00000113558	ENSG00000124762
Uniprot IDs		P63208	A0A024RCX5 P38936
PDB IDs		1FQV 1FS1 1FS2 1LDK 1P22 2ASS 2AST 2E31 2E32 2OVP 2OVQ 2OVR 3L2O 3WSO 4I6J 5IBK 5JH5 5K35 5V4B 5VZT 5VZU 5XYL 6BVA 6BYH 6C16 6M90 6M91 6M92 6M93 6M94 6O60	1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX
Enriched GO Terms of Interacting Partners?
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