SKP1 and LMO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SKP1	LMO2
Description		S-phase kinase associated protein 1	LIM domain only 2
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GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex PcG Protein Complex	Nucleoplasm Transcription Factor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding BHLH Transcription Factor Binding Metal Ion Binding Cofactor Binding E-box Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Iron Ion Homeostasis SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Post-translational Protein Modification T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Maintenance Of Protein Location In Nucleus Interleukin-1-mediated Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition	Multicellular Organism Development MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroid Hormone Stimulus Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK - noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs		1-naphthaleneacetic acid (2S)-2-(1H-indol-3-yl)hexanoic acid (2S)-2-(1H-indol-3-yl)pentanoic acid (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid 1H-INDOL-3-YLACETIC ACID
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Systemic lupus erythematosus ( 27399966 26502338)	Cognitive performance ( 19734545) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		68 interacting genes: ANKRD36BP1 APIP BTRC CACYBP CAND1 CCNA2 CDCA3 CDK2 CDK4 CDK9 CDKN1A CDKN1B CENPE CUL1 CUL7 DDX19B FBH1 FBXL2 FBXL3 FBXL4 FBXL5 FBXL6 FBXL8 FBXO15 FBXO16 FBXO17 FBXO2 FBXO25 FBXO3 FBXO32 FBXO34 FBXO4 FBXO44 FBXO5 FBXO6 FBXO7 FBXO8 FBXO9 FBXW2 FBXW5 FBXW7 FBXW8 GHR GLMN GPS1 HSP90AA1 KCTD9 LMO2 MED21 MYC NFKBIA NFKBIB NFKBIE NUDT9P1 PPARGC1A PPP1CA PTEN RBX1 SEC23B SKP2 SUGT1 TBL1X TERF1 TRRAP TTC21A TTC9C UBE2D1 UHRF2	97 interacting genes: ABI2 ADAMTSL4 AFDN AGTRAP AIMP2 ALDH6A1 AXIN1 BANP BEX2 BLZF1 C1orf94 CALCOCO2 CBY2 CCDC33 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DRAP1 EHMT2 ELF2 ERBIN FHL3 GATA1 GATA2 GATA3 GFAP GOLGA2 GRB2 HNRNPC HNRNPM HOOK1 IFT43 IHO1 IKZF3 ISL1 KANK2 KDM5A KIF3B KRT15 KRT40 KRTAP10-7 LDB1 LYL1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MRFAP1L1 MTUS2 N4BP2L2 NCAPH2 NHLH1 NIF3L1 NOTCH2NLA NUP62 NUTM1 PDE9A PHC2 PRKG1 RBBP8 REL RELA RINT1 RLIM ROCK1 SAXO1 SKP1 SMAD2 SOX5 SP1 SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TFPT TLE5 TLX3 TRIM23 TRIM54 TRIP6 TSC22D4 TUFT1 UBA6 UBE2I ZFP64 ZNF24
Entrez ID		6500	4005
HPRD ID		03255	01586
Ensembl ID		ENSG00000113558	ENSG00000135363
Uniprot IDs		P63208	P25791
PDB IDs		1FQV 1FS1 1FS2 1LDK 1P22 2ASS 2AST 2E31 2E32 2OVP 2OVQ 2OVR 3L2O 3WSO 4I6J 5IBK 5JH5 5K35 5V4B 5VZT 5VZU 5XYL 6BVA 6BYH 6C16 6M90 6M91 6M92 6M93 6M94 6O60	2XJY 2XJZ 2YPA 4KFZ
Enriched GO Terms of Interacting Partners?
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