FBXL2 and COL7A1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		FBXL2	COL7A1
Description		F-box and leucine rich repeat protein 2	collagen type VII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Golgi Membrane Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modulation By Host Of Viral RNA Genome Replication	Growth Plate Cartilage Chondrocyte Morphogenesis ER To Golgi Vesicle-mediated Transport Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Endodermal Cell Differentiation COPII Vesicle Coating
Pathways			Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures COPII-mediated vesicle transport Integrin cell surface interactions Anchoring fibril formation Laminin interactions Laminin interactions Cargo concentration in the ER Collagen chain trimerization
Drugs
Diseases			Transient bullous dermolysis of the newborn Epidermolysis bullosa, dysprophic, including: ; Epidermolysis bullosa dystrophica, AD; Epidermolysis bullosa dystrophica, AR; Epidermolysis bullosa pruriginosa; Epidermolysis bullosa, pretibial
GWAS		Heel bone mineral density ( 30598549) Rostral anterior cingulate cortex volume ( 31530798)	Age at first sexual intercourse ( 27089180) Blood protein levels ( 29875488) Bone fracture in osteoporosis ( 28580392) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		12 interacting genes: APP AURKB CCND2 CDC34 COL7A1 ITPR3 NLRP3 PIK3R2 SKP1 UBE2D1 UBE2D3 UBE2G1	15 interacting genes: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MIA3 MMP2 SHKBP1 THBS1 ZC3H7A
Entrez ID		25827	1294
HPRD ID		05736	00358
Ensembl ID		ENSG00000153558	ENSG00000114270
Uniprot IDs		Q9UKC9	Q02388 Q59F16
PDB IDs		6O60
Enriched GO Terms of Interacting Partners?
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