ARHGEF15 and CEP55

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		ARHGEF15	CEP55
Description		Rho guanine nucleotide exchange factor 15	centrosomal protein 55
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Dendrite	Cell Cytoplasm Centrosome Centriole Plasma Membrane Membrane Midbody Cleavage Furrow Centriolar Satellite Intercellular Bridge Flemming Body
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Negative Regulation Of Synapse Maturation	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Plate Congression Multicellular Organism Development Regulation Of Phosphatidylinositol 3-kinase Signaling Establishment Of Protein Localization Midbody Abscission Cranial Skeletal System Development
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) LDL cholesterol ( 30275531) Total cholesterol levels ( 30275531)	High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: C11orf49 CEP55 DNAJC5 EPHA4 ESR1 ESRRG LASP1 MOB4 PIN1	62 interacting genes: AKAP9 ANXA11 ARHGEF15 C1orf109 CCBE1 CCHCR1 CDC45 CDK1 CDSN CEP57L1 DTNB ECSIT EIF1AD FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS KIFC3 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NOS3 NTAQ1 PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RCOR3 RNF32 SDCBP SNRPB SNW1 SUPT5H TCL1A TEAD4 TEX11 TEX14 TFG TSG101 UBC VPS37C VPS37D WASHC3
Entrez ID		22899	55165
HPRD ID		10535	12569
Ensembl ID		ENSG00000198844	ENSG00000138180
Uniprot IDs		A0A0S2Z547 O94989	Q53EZ4
PDB IDs			3E1R 3WUT 3WUU 3WUV
Enriched GO Terms of Interacting Partners?
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