RNF168 and RABGEF1

Number of citations of the paper that reports this interaction (PubMedID 16499958)
117

Data Source:
HPRD (in vitro)

		RNF168	RABGEF1
Description		ring finger protein 168	RAB guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	DNA Binding Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination	Protein Targeting To Membrane Endocytosis
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		RIDDLE syndrome
GWAS		Fat distribution (HIV) ( 21897333)	Aortic root size ( 21223598) Central corneal thickness ( 29760442)
Interacting Genes		28 interacting genes: ECPAS H2AC13 H2AC18 H2AC20 H2AX H2AZ1 H2BC21 JMJD1C KDM1A KDM4A LAPTM5 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2L3 USP7 WBP2	29 interacting genes: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 DNAJC5 GGA1 GGA2 HRAS KXD1 MON1A MON1B RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		165918	27342
HPRD ID		08190	11477
Ensembl ID		ENSG00000163961	ENSG00000154710
Uniprot IDs		Q8IYW5	A0A024RDL6 A0A0A0MSJ3 A8K3R3 B3KMF1 Q9UJ41
PDB IDs		3L11 4GB0 5XIS 5XIT 5XIU 5YDK	1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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