RNF168 and JMJD1C

Number of citations of the paper that reports this interaction (PubMedID 24240613)
38

Data Source:
BioGRID (pull down)

		RNF168	JMJD1C
Description		ring finger protein 168	jumonji domain containing 1C
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break	Chromatin Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding Thyroid Hormone Receptor Binding Dioxygenase Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination	Regulation Of Transcription, DNA-templated Blood Coagulation Histone H3-K9 Demethylation Oxidation-reduction Process
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		RIDDLE syndrome
GWAS		Fat distribution (HIV) ( 21897333)	Androgen levels ( 22936694) Arthritis (juvenile idiopathic) ( 22354554) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 29875488) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) CXCL5 levels ( 25147954) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Educational attainment ( 25201988) Fasting plasma glucose ( 31170924) FEV1 ( 30804560) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gallstone disease ( 30504769) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 27863252) Intelligence (MTAG) ( 29326435) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30061609) Lung function (FVC) ( 30804560) Mean platelet volume ( 22139419 24026423 19820697 31194788 27863252) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet aggregation ( 20526338 29185836) Platelet count ( 26805783 22139419 24026423 23263863 22423221 27863252) Platelet distribution width ( 27863252) Prothrombin time ( 29403010) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 31666285 29403010) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 28334899 29403010) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565) Type 2 diabetes ( 28406950) Urate levels ( 31578528) Vascular endothelial growth factor levels ( 26910538 27989323) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 27863252)
Interacting Genes		28 interacting genes: ECPAS H2AC13 H2AC18 H2AC20 H2AX H2AZ1 H2BC21 JMJD1C KDM1A KDM4A LAPTM5 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2L3 USP7 WBP2	13 interacting genes: AR ESR2 GADD45A MT2A NUDT21 PPARG PSMC1 RNF168 RNF8 RXRA SRPK2 THRB TK1
Entrez ID		165918	221037
HPRD ID		08190	05141
Ensembl ID		ENSG00000163961	ENSG00000171988
Uniprot IDs		Q8IYW5	B7ZLC8 Q15652
PDB IDs		3L11 4GB0 5XIS 5XIT 5XIU 5YDK	2YPD 5FZO
Enriched GO Terms of Interacting Partners?
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