TTC23L and EGLN3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TTC23L	EGLN3
Description		tetratricopeptide repeat domain 23 like	egl-9 family hypoxia inducible factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Spindle Midbody	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Response To Endoplasmic Reticulum Stress	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways			Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Vitamin C Roxadustat
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Dysphagia ( 26116289)	Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)
Interacting Genes		6 interacting genes: CALCOCO2 CBY1 EGLN3 EXOC5 MIA2 UBE3A	25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83
Entrez ID		153657	112399
HPRD ID		08691	06972
Ensembl ID		ENSG00000205838	ENSG00000129521
Uniprot IDs		A0A3B3IS63 Q6PF05	B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9
PDB IDs
Enriched GO Terms of Interacting Partners?
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