GRAP and LAT

Number of citations of the paper that reports this interaction (PubMedID 9489702)
311

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GRAP	LAT
Description		GRB2 related adaptor protein	linker for activation of T cells
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Cell Junction Presynapse	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound Positive Regulation Of Signal Transduction	MAPK Cascade Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Signaling by SCF-KIT	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Copper levels ( 26025379)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		14 interacting genes: ARHGAP32 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 RBPMS SHC1 SOS1 TRIM21	33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2
Entrez ID		10750	27040
HPRD ID		05062	03832
Ensembl ID		ENSG00000154016	ENSG00000213658
Uniprot IDs		I3L2P9 Q13588	A0A024QZD6 O43561
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?