LAT and ZHX2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		LAT	ZHX2
Description		linker for activation of T cells	zinc fingers and homeoboxes 2
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft	Nuclear Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	MAPK Cascade Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Negative Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Retinal Bipolar Neuron Differentiation
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Carotid intima media thickness ( 30510157 21909108) Chin dimples ( 27182965) Immune response to smallpox vaccine (IL-6) ( 22542470)
Interacting Genes		33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2	10 interacting genes: APP ATXN1 DHRS2 LAT NAGPA NFYA RAB7A YWHAQ ZHX1 ZHX3
Entrez ID		27040	22882
HPRD ID		03832	16458
Ensembl ID		ENSG00000213658	ENSG00000178764
Uniprot IDs		A0A024QZD6 O43561	Q9Y6X8
PDB IDs			2DMP 3NAU
Enriched GO Terms of Interacting Partners?
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