LAT and SLA

Number of citations of the paper that reports this interaction (PubMedID 10449770)
20

Data Source:
HPRD (in vivo)

		LAT	SLA
Description		linker for activation of T cells	Src like adaptor
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft	Endosome Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding	Non-membrane Spanning Protein Tyrosine Kinase Activity SH3/SH2 Adaptor Activity Signaling Receptor Binding Protein Binding
	Biological Process	MAPK Cascade Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Bone erosion in rheumatoid arthritis ( 28512992) Graves' disease ( 23612905) Multiple sclerosis ( 31604244) Temperament ( 22832960) Vitiligo ( 27723757 22561518)
Interacting Genes		33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2	14 interacting genes: CBL CD247 EGFR EPHA2 ERBB2 FGFR1 FLT3 GSK3B LAT PAFAH1B2 SYK UBE4A VAV1 ZAP70
Entrez ID		27040	6503
HPRD ID		03832	03060
Ensembl ID		ENSG00000213658	ENSG00000155926
Uniprot IDs		A0A024QZD6 O43561	Q13239
PDB IDs			2CUD
Enriched GO Terms of Interacting Partners?
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