GRAP and TRIM21

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GRAP	TRIM21
Description		GRB2 related adaptor protein	tripartite motif containing 21
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Cell Junction Presynapse	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound Positive Regulation Of Signal Transduction	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Interferon-gamma Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Signaling by SCF-KIT	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Copper levels ( 26025379)	Lung cancer ( 28604730)
Interacting Genes		14 interacting genes: ARHGAP32 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 RBPMS SHC1 SOS1 TRIM21	52 interacting genes: APC CALR CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GABARAP GABARAPL1 GABARAPL2 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NIF3L1 PFKP RBCK1 RNF111 RO60 SKP2 SQSTM1 TBK1 TRIM27 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2H UBE2I UBE2L3 UBE2N UBE2V2 UBE2W USP15 USP2 USP4 YWHAZ
Entrez ID		10750	6737
HPRD ID		05062	00170
Ensembl ID		ENSG00000154016	ENSG00000132109
Uniprot IDs		I3L2P9 Q13588	P19474
PDB IDs			2IWG 5JPX 5OLM 6FGA 6S53
Enriched GO Terms of Interacting Partners?
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