SMC2 and DNMT3B

Number of citations of the paper that reports this interaction (PubMedID 15148359)
46

Data Source:
BioGRID (biochemical, pull down)

		SMC2	DNMT3B
Description		structural maintenance of chromosomes 2	DNA methyltransferase 3 beta
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GO Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Condensin Complex Condensin Core Heterodimer Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia DNA Methylation Response To Toxic Substance Response To Ionizing Radiation Positive Regulation Of Gene Expression Response To Activity Response To Caffeine Response To Estradiol Response To Vitamin A Response To Cocaine Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus C-5 Methylation Of Cytosine
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation
Drugs
Diseases			Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Basal cell carcinoma ( 31174203) Keratinocyte cancer (MTAG) ( 31174203) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Sensorimotor dexterity ( 31596458)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Nicotine dependence ( 28972577) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)
Interacting Genes		9 interacting genes: ABCC5 DISC1 DNMT3B ERP44 GULP1 LIG4 NCAPD2 SMC4 TRAF3IP1	38 interacting genes: BAZ2A CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18
Entrez ID		10592	1789
HPRD ID		09277	04209
Ensembl ID		ENSG00000136824	ENSG00000088305
Uniprot IDs		A0A024R158 A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1	Q9UBC3
PDB IDs		4U4P	3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO
Enriched GO Terms of Interacting Partners?
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