DNMT3B and TSC22D1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		DNMT3B	TSC22D1
Description		DNA methyltransferase 3 beta	TSC22 domain family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia DNA Methylation Response To Toxic Substance Response To Ionizing Radiation Positive Regulation Of Gene Expression Response To Activity Response To Caffeine Response To Estradiol Response To Vitamin A Response To Cocaine Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus C-5 Methylation Of Cytosine	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation
Drugs
Diseases		Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Nicotine dependence ( 28972577) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Rosacea symptom severity ( 29771307)
Interacting Genes		38 interacting genes: BAZ2A CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18	50 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GTF2F2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1
Entrez ID		1789	8848
HPRD ID		04209	07414
Ensembl ID		ENSG00000088305	ENSG00000102804
Uniprot IDs		Q9UBC3	A0A024RDV8 A0A087X0H8 A8K3Y6 Q15714
PDB IDs		3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO
Enriched GO Terms of Interacting Partners?
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