DNMT3B and ZBTB18

Number of citations of the paper that reports this interaction (PubMedID 11350943)
152

Data Source:
HPRD (in vitro)

		DNMT3B	ZBTB18
Description		DNA methyltransferase 3 beta	zinc finger and BTB domain containing 18
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nuclear Chromosome Nucleus Nuclear Speck
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding	DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia DNA Methylation Response To Toxic Substance Response To Ionizing Radiation Positive Regulation Of Gene Expression Response To Activity Response To Caffeine Response To Estradiol Response To Vitamin A Response To Cocaine Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus C-5 Methylation Of Cytosine	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Skeletal Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation
Drugs
Diseases		Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Nicotine dependence ( 28972577) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)	Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258) Mercury levels ( 26025379)
Interacting Genes		38 interacting genes: BAZ2A CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18	7 interacting genes: CTBP1 CTBP2 DNMT3A DNMT3B PAK1 POMGNT1 TSN
Entrez ID		1789	10472
HPRD ID		04209	12231
Ensembl ID		ENSG00000088305	ENSG00000179456
Uniprot IDs		Q9UBC3	Q99592
PDB IDs		3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO
Enriched GO Terms of Interacting Partners?
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