| Novel |
ATP2A2
|
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
- Pre-NOTCH Processing in Golgi
- Reduction of cytosolic Ca++ levels
- Ion homeostasis
- Ion transport by P-type ATPases
|
- Ritodrine
- Desflurane
- Sevoflurane
- Istaroxime
|
- Acrokeratosis verruciformis
- Darier disease; Dyskeratosis follicularis
|
| Novel |
CCDC33
|
coiled-coil domain containing 33 |
|
|
|
| Novel |
CRY1
|
cryptochrome circadian regulator 1 |
- Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
- The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
- Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
- Degradation of CRY and PER proteins
|
|
|
| Novel |
DAO
|
D-amino acid oxidase |
- Glyoxylate metabolism and glycine degradation
- Peroxisomal protein import
- Peroxisomal protein import
|
- 3,4-Dihydro-2h-Pyrrolium-5-Carboxylate
- Imino-Tryptophan
- Flavin adenine dinucleotide
- D-Tryptophan
- Flavin-adenine dinucleotide-N5-isobutyl ketone
- Benzoic acid
- Anthranilic acid
- (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
|
|
| Novel |
FTH1
|
ferritin heavy chain 1 |
- Scavenging by Class A Receptors
- Golgi Associated Vesicle Biogenesis
- Neutrophil degranulation
- Iron uptake and transport
|
- Iron Dextran
- Iron
- Ferric pyrophosphate citrate
- Ferrous gluconate
- Ferrous succinate
- Ferrous ascorbate
- Ferrous fumarate
- Ferrous glycine sulfate
|
|
| Novel |
KERA
|
keratocan |
- Keratan sulfate biosynthesis
- Keratan sulfate degradation
- Defective CHST6 causes MCDC1
- Defective ST3GAL3 causes MCT12 and EIEE15
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
|
|
|
| Novel |
P2RY6
|
pyrimidinergic receptor P2Y6 |
- G alpha (q) signalling events
- P2Y receptors
|
|
|
| Novel |
PRDM4
|
PR/SET domain 4 |
- p75NTR negatively regulates cell cycle via SC1
|
|
|
| Novel |
RPS20
|
ribosomal protein S20 |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Peptide chain elongation
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- Viral mRNA Translation
- Selenocysteine synthesis
- Major pathway of rRNA processing in the nucleolus and cytosol
- Translation initiation complex formation
- Formation of a pool of free 40S subunits
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Termination
- Regulation of expression of SLITs and ROBOs
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- SARS-CoV-1 modulates host translation machinery
- SARS-CoV-2 modulates host translation machinery
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
- ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
|
|
|
| Novel |
SLC17A7
|
solute carrier family 17 member 7 |
- Glutamate Neurotransmitter Release Cycle
- SLC-mediated transport of neurotransmitters
|
|
|
|
APP
|
amyloid beta precursor protein |
- Platelet degranulation
- ECM proteoglycans
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- G alpha (q) signalling events
- G alpha (i) signalling events
- Lysosome Vesicle Biogenesis
- Formyl peptide receptors bind formyl peptides and many other ligands
- TAK1-dependent IKK and NF-kappa-B activation
- The NLRP3 inflammasome
- Advanced glycosylation endproduct receptor signaling
- Advanced glycosylation endproduct receptor signaling
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Post-translational protein phosphorylation
- TRAF6 mediated NF-kB activation
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Purinergic signaling in leishmaniasis infection
- Amyloid fiber formation
|
- Deferoxamine
- Aluminium
- Zinc
- L-methionine (R)-S-oxide
- Resveratrol
- Tromethamine
- Phenserine
- Tetrathiomolybdate
- CAD106
- Mito-4509
- Edonerpic
- Dimercaprol
- Copper
- Florbetaben (18F)
- Florbetapir (18F)
- Flutemetamol (18F)
- Gantenerumab
- Aducanumab
- Zinc acetate
- Aluminium phosphate
- Aluminum acetate
- Zinc chloride
- Zinc sulfate, unspecified form
- Lecanemab
|
|
|
CAPN11
|
calpain 11 |
- Degradation of the extracellular matrix
|
|
|
|
CEBPA
|
CCAAT enhancer binding protein alpha |
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
|
|
- Acute myeloid leukemia (AML)
|
|
PCNA
|
proliferating cell nuclear antigen |
- Translesion synthesis by REV1
- Recognition of DNA damage by PCNA-containing replication complex
- Translesion Synthesis by POLH
- Transcription of E2F targets under negative control by DREAM complex
- Polymerase switching on the C-strand of the telomere
- Processive synthesis on the C-strand of the telomere
- Telomere C-strand (Lagging Strand) Synthesis
- Removal of the Flap Intermediate from the C-strand
- SUMOylation of DNA replication proteins
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- PCNA-Dependent Long Patch Base Excision Repair
- Translesion synthesis by POLK
- Translesion synthesis by POLI
- Termination of translesion DNA synthesis
- HDR through Homologous Recombination (HRR)
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- Polymerase switching
- Removal of the Flap Intermediate
- Processive synthesis on the lagging strand
- G1/S-Specific Transcription
- E3 ubiquitin ligases ubiquitinate target proteins
|
- Liothyronine
- Acetylsalicylic acid
|
|
|
RPA2
|
replication protein A2 |
- Translesion synthesis by REV1
- Recognition of DNA damage by PCNA-containing replication complex
- Translesion Synthesis by POLH
- Removal of the Flap Intermediate from the C-strand
- Activation of ATR in response to replication stress
- Regulation of HSF1-mediated heat shock response
- HSF1 activation
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- PCNA-Dependent Long Patch Base Excision Repair
- Translesion synthesis by POLK
- Translesion synthesis by POLI
- Termination of translesion DNA synthesis
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Formation of Incision Complex in GG-NER
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Fanconi Anemia Pathway
- Regulation of TP53 Activity through Phosphorylation
- Activation of the pre-replicative complex
- Removal of the Flap Intermediate
- G2/M DNA damage checkpoint
- Meiotic recombination
- Impaired BRCA2 binding to RAD51
|
|
|
|
SEZ6L2
|
seizure related 6 homolog like 2 |
|
|
|