UNG and SLC17A7

		UNG	SLC17A7
Description		uracil DNA glycosylase	solute carrier family 17 member 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Neuron Projection Cerebellar Mossy Fiber Synapse Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Glutamate Transport Vesicle Membrane Postsynapse
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Ribosomal Small Subunit Binding	Chloride Channel Activity L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Sodium:phosphate Symporter Activity Extracellularly Glutamate-gated Chloride Channel Activity Secondary Active Transmembrane Transporter Activity Symporter Activity Antiporter Activity Potassium:proton Antiporter Activity Transmembrane Transporter Activity Phosphate Ion Uniporter Activity L-glutamate Uniporter Activity
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal	Neural Retina Development Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Phosphate Ion Transport Chloride Transport Neurotransmitter Transport Chemical Synaptic Transmission Long-term Memory L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sodium-dependent Phosphate Transport Regulation Of Synapse Structure Or Activity Establishment Of Localization In Cell L-glutamate Import Phosphate Ion Homeostasis Transmembrane Transport Excitatory Postsynaptic Potential Potassium Ion Transmembrane Transport Synaptic Vesicle Lumen Acidification Neurotransmitter Loading Into Synaptic Vesicle Regulation Of Synaptic Vesicle Endocytosis Chloride Transmembrane Transport
Pathways			Glutamate Neurotransmitter Release Cycle SLC-mediated transport of neurotransmitters
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		6 interacting genes: APP CAPN11 CEBPA PCNA RPA2 SEZ6L2	1 interacting genes: SH3GL2
Entrez ID		7374	57030
HPRD ID		01881	05551
Ensembl ID		ENSG00000076248	ENSG00000104888
Uniprot IDs		E5KTA5 E5KTA6 P13051	Q9P2U7
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7 6VBA 7V7C
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Structure Or Activity Amyloid-beta Complex Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Chemical Homeostasis Homeostatic Process Enzyme Binding Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process Memory P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Longitudinal Sarcoplasmic Reticulum RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Regulation Of DNA Damage Checkpoint FAD Binding Presynaptic Active Zone D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide PCNA Complex Replisome Mismatch Repair Response To Ketone Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Cellular Response To Stress Positive Regulation Of Protein Import Calcium Ion-transporting ATPase Complex Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Neuron Cellular Homeostasis Cellular Response To Xenobiotic Stimulus Animal Organ Regeneration Response To Vitamin B2 C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity	Postsynaptic Cytoskeleton Organization Regulation Of Blood-brain Barrier Permeability Dendrite Extension Presynaptic Cytosol Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Blood-brain Barrier Permeability Photoreceptor Ribbon Synapse Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Somatic Hypermutation Of Immunoglobulin Genes Deoxyribose Phosphate Catabolic Process Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal Base-excision Repair, AP Site Formation Single Strand Break Repair Ribosomal Small Subunit Binding Uracil DNA N-glycosylase Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Diversification Of Immune Receptors Via Somatic Mutation Deoxyribonucleotide Catabolic Process Pyrimidine Deoxyribonucleotide Catabolic Process Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Depyrimidination DNA Modification Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Pyrimidine-containing Compound Catabolic Process Negative Regulation Of ERBB Signaling Pathway Somatic Recombination Of Immunoglobulin Gene Segments Presynaptic Endocytosis Response To Nerve Growth Factor Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus Deoxyribonucleotide Metabolic Process Base-excision Repair Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Regulation Of Vascular Permeability Pyrimidine Nucleotide Metabolic Process B Cell Activation Involved In Immune Response Damaged DNA Binding Clathrin-coated Endocytic Vesicle Membrane Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Pyrimidine-containing Compound Metabolic Process Regulation Of Receptor Internalization Neuron Projection Extension Vesicle-mediated Transport In Synapse Nucleotide Catabolic Process Regulation Of Receptor-mediated Endocytosis
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