|
Novel |
ATP6V1C1 |
ATPase H+ transporting V1 subunit C1 |
- ROS and RNS production in phagocytes
- Insulin receptor recycling
- Transferrin endocytosis and recycling
- Amino acids regulate mTORC1
- Ion channel transport
- Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
|
- Tiludronic acid
- D-tartaric acid
- Thonzonium
|
|
|
Novel |
DCAF13 |
DDB1 and CUL4 associated factor 13 |
- rRNA modification in the nucleus and cytosol
- Major pathway of rRNA processing in the nucleolus and cytosol
- Neddylation
|
|
|
|
Novel |
LRP12 |
LDL receptor related protein 12 |
- Retinoid metabolism and transport
|
|
|
|
Novel |
LRP1B |
LDL receptor related protein 1B |
|
|
|
|
Novel |
MET |
MET proto-oncogene, receptor tyrosine kinase |
- PIP3 activates AKT signaling
- Constitutive Signaling by Aberrant PI3K in Cancer
- Sema4D mediated inhibition of cell attachment and migration
- RAF/MAP kinase cascade
- MET Receptor Activation
- Negative regulation of MET activity
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- MET activates RAS signaling
- MET activates PI3K/AKT signaling
- MET activates PTPN11
- MET activates PTK2 signaling
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlB-mediated entry of Listeria monocytogenes into host cell
- MET interacts with TNS proteins
- MET activates RAP1 and RAC1
- MET receptor recycling
- MET activates STAT3
- MECP2 regulates neuronal receptors and channels
- Drug-mediated inhibition of MET activation
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
|
- Sunitinib
- K-252a
- SGX-523
- 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
- N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
- 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
- N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
- 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol
- AMG-208
- 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE
- Crizotinib
- Cabozantinib
- Capmatinib
- Tivozanib
- Fostamatinib
- Tivantinib
- Brigatinib
- Amuvatinib
- Tepotinib
- Amivantamab
|
- Cholangiocarcinoma
- Gastric cancer
- Renal cell carcinoma
|
|
Novel |
ODF1 |
outer dense fiber of sperm tails 1 |
|
|
|
|
Novel |
PCED1A |
PC-esterase domain containing 1A |
|
|
|
|
Novel |
PITPNA |
phosphatidylinositol transfer protein alpha |
- Role of second messengers in netrin-1 signaling
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
|
- 1,2-diacyl-sn-glycero-3-phosphoinositol
- (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
|
|
|
Novel |
RIMS2 |
regulating synaptic membrane exocytosis 2 |
|
|
|
|
|
ANAPC5 |
anaphase promoting complex subunit 5 |
- Inactivation of APC/C via direct inhibition of the APC/C complex
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- Assembly of the pre-replicative complex
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
APBB1 |
amyloid beta precursor protein binding family B member 1 |
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
|
|
|
|
|
ATXN2 |
ataxin 2 |
|
|
- Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
|
|
|
CARM1 |
coactivator associated arginine methyltransferase 1 |
- BMAL1:CLOCK,NPAS2 activates circadian expression
- PPARA activates gene expression
- PPARA activates gene expression
- Transcriptional activation of mitochondrial biogenesis
- Activation of gene expression by SREBF (SREBP)
- RMTs methylate histone arginines
- Transcriptional regulation of white adipocyte differentiation
- Regulation of lipid metabolism by PPARalpha
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- Estrogen-dependent gene expression
- Cytoprotection by HMOX1
- Heme signaling
- Expression of BMAL (ARNTL), CLOCK, and NPAS2
- RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
|
|
|
|
|
CEBPA |
CCAAT enhancer binding protein alpha |
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
|
|
- Acute myeloid leukemia (AML)
|
|
|
CHAF1A |
chromatin assembly factor 1 subunit A |
|
|
|
|
|
CNOT6 |
CCR4-NOT transcription complex subunit 6 |
- Deadenylation of mRNA
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- M-decay: degradation of maternal mRNAs by maternally stored factors
|
|
|
|
|
CNOT7 |
CCR4-NOT transcription complex subunit 7 |
- Deadenylation of mRNA
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- M-decay: degradation of maternal mRNAs by maternally stored factors
|
|
|
|
|
CSDE1 |
cold shock domain containing E1 |
|
|
|
|
|
DUX4 |
double homeobox 4 |
- Zygotic genome activation (ZGA)
- Zygotic genome activation (ZGA)
|
|
|
|
|
EIF4B |
eukaryotic translation initiation factor 4B |
- L13a-mediated translational silencing of Ceruloplasmin expression
- mTORC1-mediated signalling
- Deadenylation of mRNA
- Deadenylation of mRNA
- Translation initiation complex formation
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- M-decay: degradation of maternal mRNAs by maternally stored factors
- Z-decay: degradation of maternal mRNAs by zygotically expressed factors
|
|
|