Search Results for: NGLY1

26 interactions involving NGLY1 - N-glycanase 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Symbol Description Pathways Hide Drugs Hide Diseases Hide
Novel GJB2 gap junction protein beta 2
  • Oligomerization of connexins into connexons
  • Transport of connexins along the secretory pathway
  • Gap junction assembly
  • Transport of connexons to the plasma membrane
  • Deafness, autosomal recessive
  • Keratitis-ichthyosis-deafness syndrome
  • Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis
  • Deafness, autosomal dominant
  • Palmoplantar keratoderma with deafness
Novel GRM7 glutamate metabotropic receptor 7
  • G alpha (i) signalling events
  • Class C/3 (Metabotropic glutamate/pheromone receptors)
  • Glutamic acid
Novel LIMD1 LIM domain containing 1
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Novel MAP3K2 mitogen-activated protein kinase kinase kinase 2
  • Bosutinib
  • Fostamatinib
Novel OPA3 outer mitochondrial membrane lipid metabolism regulator OPA3
  • Autosomal dominant optic atrophy (DOA); Kjer's optic neuropathy
  • 3-Methylglutaconic aciduria (MGCA)
Novel PROC protein C, inactivator of coagulation factors Va and VIIIa
  • Intrinsic Pathway of Fibrin Clot Formation
  • Common Pathway of Fibrin Clot Formation
  • Gamma-carboxylation of protein precursors
  • Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
  • Removal of aminoterminal propeptides from gamma-carboxylated proteins
  • Cell surface interactions at the vascular wall
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
  • Menadione
  • Sodium tetradecyl sulfate
  • Cupric Chloride
  • Kappadione
  • Protein S human
  • Inherited thrombophilia
Novel SH3BP1 SH3 domain binding protein 1
  • RAC1 GTPase cycle
APP amyloid beta precursor protein
  • Platelet degranulation
  • ECM proteoglycans
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • G alpha (q) signalling events
  • G alpha (i) signalling events
  • Lysosome Vesicle Biogenesis
  • Formyl peptide receptors bind formyl peptides and many other ligands
  • TAK1-dependent IKK and NF-kappa-B activation
  • The NLRP3 inflammasome
  • Advanced glycosylation endproduct receptor signaling
  • Advanced glycosylation endproduct receptor signaling
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Post-translational protein phosphorylation
  • TRAF6 mediated NF-kB activation
  • Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
  • Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
  • Purinergic signaling in leishmaniasis infection
  • Amyloid fiber formation
  • Deferoxamine
  • Aluminium
  • Zinc
  • L-methionine (R)-S-oxide
  • Resveratrol
  • Tromethamine
  • Phenserine
  • Tetrathiomolybdate
  • CAD106
  • Mito-4509
  • Edonerpic
  • Dimercaprol
  • Copper
  • Florbetaben (18F)
  • Florbetapir (18F)
  • Flutemetamol (18F)
  • Gantenerumab
  • Aducanumab
  • Zinc acetate
  • Aluminium phosphate
  • Aluminum acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
  • Lecanemab
  • Alzheimer's disease (AD)
BICRAL BICRA like chromatin remodeling complex associated protein
  • Formation of the non-canonical BAF (ncBAF) complex
FAF1 Fas associated factor 1
GUCD1 guanylyl cyclase domain containing 1
NPAS2 neuronal PAS domain protein 2
  • BMAL1:CLOCK,NPAS2 activates circadian expression
  • PPARA activates gene expression
  • Heme signaling
  • Expression of BMAL (ARNTL), CLOCK, and NPAS2
  • Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
  • The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
NSFL1C NSFL1 cofactor
  • RHOH GTPase cycle
PAX5 paired box 5
  • RUNX1 regulates transcription of genes involved in BCR signaling
  • Lymphoplasmacytic lymphoma
PAX6 paired box 6
  • Regulation of gene expression in beta cells
  • Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
  • Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Formation of the anterior neural plate
  • Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON)
  • Aniridia
  • Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
RAD23A RAD23 nucleotide excision repair protein A
  • Josephin domain DUBs
  • DNA Damage Recognition in GG-NER
  • Formation of Incision Complex in GG-NER
RAD23B RAD23 nucleotide excision repair protein B
  • N-glycan trimming in the ER and Calnexin/Calreticulin cycle
  • Josephin domain DUBs
  • DNA Damage Recognition in GG-NER
  • Formation of Incision Complex in GG-NER
SRPK2 SRSF protein kinase 2
  • Maturation of nucleoprotein
  • Adenine
  • Purvalanol
  • Phosphoaminophosphonic Acid-Adenylate Ester
TCF12 transcription factor 12
  • Myogenesis
  • Myogenesis
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • NGF-stimulated transcription
  • NGF-stimulated transcription
  • Negative Regulation of CDH1 Gene Transcription
  • TGFBR3 expression
TRAFD1 TRAF-type zinc finger domain containing 1

Page 1 out of 2 pages