IMPDH2 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ALS2	alsin Rho guanine nucleotide exchange factor ALS2	RAB GEFs exchange GTP for GDP on RABs RAC1 GTPase cycle		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
Novel	AMT	aminomethyltransferase	Glycine degradation	Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid	Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
Novel	APPL1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Caspase activation via Dependence Receptors in the absence of ligand
Novel	ATXN2	ataxin 2			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Novel	ATXN7	ataxin 7	HATs acetylate histones Ub-specific processing proteases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Novel	C1S	complement C1s	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form Sutimlimab	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
Novel	CEACAM5	CEA cell adhesion molecule 5	Post-translational modification: synthesis of GPI-anchored proteins Cell surface interactions at the vascular wall	Labetuzumab S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Novel	DCAF1	DDB1 and CUL4 associated factor 1	Antigen processing: Ubiquitination & Proteasome degradation
Novel	DNASE1L3	deoxyribonuclease 1L3
Novel	FBXL7	F-box and leucine rich repeat protein 7	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Novel	KLF7	KLF transcription factor 7
Novel	PRMT1	protein arginine methyltransferase 1	RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression Maturation of nucleoprotein	S-adenosyl-L-homocysteine
Novel	PXMP2	peroxisomal membrane protein 2	Glyoxylate metabolism and glycine degradation Class I peroxisomal membrane protein import
Novel	PXN	paxillin	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Novel	RAD54L2	RAD54 like 2
Novel	RBM15B	RNA binding motif protein 15B
	AGR2	anterior gradient 2, protein disulphide isomerase family member
	AKT1	AKT serine/threonine kinase 1	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Mitochondrial unfolded protein response (UPRmt) High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol Archexin Enzastaurin Perifosine N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine	PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
	APIP	APAF1 interacting protein	Formation of apoptosome Methionine salvage pathway Regulation of the apoptosome activity
	CEBPA	CCAAT enhancer binding protein alpha	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis		Acute myeloid leukemia (AML)

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