| Novel |
CASP8
|
caspase 8 |
- Apoptotic cleavage of cellular proteins
- Caspase activation via Death Receptors in the presence of ligand
- NOD1/2 Signaling Pathway
- TRIF-mediated programmed cell death
- Caspase-mediated cleavage of cytoskeletal proteins
- Regulation by c-FLIP
- RIPK1-mediated regulated necrosis
- CASP8 activity is inhibited
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- CLEC7A/inflammasome pathway
- Regulation of necroptotic cell death
- Dimerization of procaspase-8
- Activation, myristolyation of BID and translocation to mitochondria
- Apoptotic execution phase
- FasL/ CD95L signaling
- TRAIL signaling
- TLR3-mediated TICAM1-dependent programmed cell death
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- Microbial modulation of RIPK1-mediated regulated necrosis
- Defective RIPK1-mediated regulated necrosis
- Regulation of NF-kappa B signaling
|
- Trichostatin A
- AN-9
- Bryostatin 1
- Bardoxolone
- Oleandrin
|
- Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
|
| Novel |
CBLB
|
Cbl proto-oncogene B |
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
| Novel |
CLTA
|
clathrin light chain A |
- Entry of Influenza Virion into Host Cell via Endocytosis
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Gap junction degradation
- Formation of annular gap junctions
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Lysosome Vesicle Biogenesis
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
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|
|
| Novel |
HTT
|
huntingtin |
- Regulation of MECP2 expression and activity
|
|
- Huntington's disease (HD)
|
| Novel |
SLC25A3
|
solute carrier family 25 member 3 |
|
|
|
| Novel |
TERT
|
telomerase reverse transcriptase |
- Telomere Extension By Telomerase
- Formation of the beta-catenin:TCF transactivating complex
- Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
|
- Zidovudine
- Grn163l
- Tertomotide
|
- Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
|
|
EXOC5
|
exocyst complex component 5 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Insulin processing
- VxPx cargo-targeting to cilium
|
|
|
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HIP1
|
huntingtin interacting protein 1 |
- Clathrin-mediated endocytosis
- ALK mutants bind TKIs
- Signaling by ALK fusions and activated point mutants
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|
|
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IFT20
|
intraflagellar transport 20 |
- Intraflagellar transport
- Intraflagellar transport
|
|
|
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SKA2
|
spindle and kinetochore associated complex subunit 2 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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|
|
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UBXN10
|
UBX domain protein 10 |
|
|
|
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WASHC1
|
WASH complex subunit 1 |
|
|
|
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YAF2
|
YY1 associated factor 2 |
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Transcriptional Regulation by E2F6
|
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|
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ZDHHC17
|
zDHHC palmitoyltransferase 17 |
|
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