| Novel |
CIMIP4
|
ciliary microtubule inner protein 4 |
|
|
|
| Novel |
PDGFB
|
platelet derived growth factor subunit B |
- Platelet degranulation
- PIP3 activates AKT signaling
- Downstream signal transduction
- Signaling by PDGF
- Constitutive Signaling by Aberrant PI3K in Cancer
- Non-integrin membrane-ECM interactions
- RAF/MAP kinase cascade
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
|
|
- Glioma
- Malignant pleural mesothelioma
|
| Novel |
SNF8
|
SNF8 subunit of ESCRT-II |
- Endosomal Sorting Complex Required For Transport (ESCRT)
- HCMV Late Events
|
|
|
| Novel |
ZNF132
|
zinc finger protein 132 |
|
|
|
|
AKT1
|
AKT serine/threonine kinase 1 |
- Activation of BAD and translocation to mitochondria
- PIP3 activates AKT signaling
- PIP3 activates AKT signaling
- Downregulation of ERBB2:ERBB3 signaling
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- MTOR signalling
- AKT phosphorylates targets in the cytosol
- AKT phosphorylates targets in the cytosol
- AKT phosphorylates targets in the nucleus
- Negative regulation of the PI3K/AKT network
- eNOS activation
- AKT-mediated inactivation of FOXO1A
- Integrin signaling
- Deactivation of the beta-catenin transactivating complex
- CD28 dependent PI3K/Akt signaling
- Co-inhibition by CTLA4
- G beta:gamma signalling through PI3Kgamma
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- KSRP (KHSRP) binds and destabilizes mRNA
- VEGFR2 mediated vascular permeability
- TP53 Regulates Metabolic Genes
- Constitutive Signaling by AKT1 E17K in Cancer
- Interleukin-4 and Interleukin-13 signaling
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Acetylation
- Regulation of TP53 Activity through Association with Co-factors
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Cyclin E associated events during G1/S transition
- Cyclin A:Cdk2-associated events at S phase entry
- PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
- RAB GEFs exchange GTP for GDP on RABs
- RUNX2 regulates genes involved in cell migration
- Regulation of PTEN stability and activity
- Extra-nuclear estrogen signaling
- Negative regulation of NOTCH4 signaling
- FLT3 Signaling
- Regulation of localization of FOXO transcription factors
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- KEAP1-NFE2L2 pathway
- SARS-CoV-2 targets host intracellular signalling and regulatory pathways
- Mitochondrial unfolded protein response (UPRmt)
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
- Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
|
- ATP
- Arsenic trioxide
- Genistein
- Inositol 1,3,4,5-Tetrakisphosphate
- Resveratrol
- Archexin
- Enzastaurin
- Perifosine
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
|
- PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
|
|
AQP6
|
aquaporin 6 |
- Passive transport by Aquaporins
|
|
|
|
ARL13B
|
ARF like GTPase 13B |
- ARL13B-mediated ciliary trafficking of INPP5E
- RHOQ GTPase cycle
- RHOJ GTPase cycle
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Aggrephagy
- Aggrephagy
|
|
|
|
ASL
|
argininosuccinate lyase |
|
- Arginine
- Argininosuccinate
- 2-(N-morpholino)ethanesulfonic acid
|
- Argininosuccinic aciduria (ARGINSA); Argininosuccinate lyase deficiency
|
|
BLVRB
|
biliverdin reductase B |
- Heme degradation
- Cytoprotection by HMOX1
|
- Riboflavin
- NADH
- Biliverdine IX Alpha
- Flavin mononucleotide
- Nicotinamide adenine dinucleotide phosphate
- Lumichrome
- Mesobiliverdin IV alpha
|
|
|
CD79A
|
CD79a molecule |
- CD22 mediated BCR regulation
- Potential therapeutics for SARS
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
|
|
- Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
|
|
COQ9
|
coenzyme Q9 |
|
|
|
|
CPLX4
|
complexin 4 |
|
|
|
|
CPSF1
|
cleavage and polyadenylation specific factor 1 |
- Transport of Mature mRNA Derived from an Intronless Transcript
- tRNA processing in the nucleus
- mRNA 3'-end processing
- Processing of Capped Intron-Containing Pre-mRNA
- RNA Polymerase II Transcription Termination
- Processing of Intronless Pre-mRNAs
|
|
|
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CRB3
|
crumbs cell polarity complex component 3 |
- Tight junction interactions
- SARS-CoV-2 targets PDZ proteins in cell-cell junction
|
|
|
|
CREB3
|
cAMP responsive element binding protein 3 |
- CREB3 factors activate genes
- CREB3 factors activate genes
|
|
|
|
CYB561
|
cytochrome b561 |
|
|
|
|
CYBRD1
|
cytochrome b reductase 1 |
- Iron uptake and transport
|
|
|
|
ELOVL4
|
ELOVL fatty acid elongase 4 |
- Synthesis of very long-chain fatty acyl-CoAs
|
|
- Stargardt disease (STGD); Fundus flavimaculatus
|
|
ELOVL5
|
ELOVL fatty acid elongase 5 |
- Linoleic acid (LA) metabolism
- alpha-linolenic acid (ALA) metabolism
- Synthesis of very long-chain fatty acyl-CoAs
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
|
|
|
|
ELOVL6
|
ELOVL fatty acid elongase 6 |
- Activation of gene expression by SREBF (SREBP)
- Synthesis of very long-chain fatty acyl-CoAs
|
|
|