F2RL1 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ANKRA2	ankyrin repeat family A member 2
Novel	CYFIP2	cytoplasmic FMR1 interacting protein 2	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Novel	F2R	coagulation factor II thrombin receptor	Common Pathway of Fibrin Clot Formation Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs)	Streptokinase SR-123781A Vorapaxar Thrombin
Novel	JMY	junction mediating and regulatory protein, p53 cofactor	Regulation of TP53 Activity through Methylation
Novel	MAP1B	microtubule associated protein 1B	RSV-host interactions
Novel	NUMA1	nuclear mitotic apparatus protein 1	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
Novel	PCBD2	pterin-4 alpha-carbinolamine dehydratase 2
Novel	RAD17	RAD17 checkpoint clamp loader component	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
	ABCC8	ATP binding cassette subfamily C member 8	ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias	ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine	Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
	ABHD14A	abhydrolase domain containing 14A
	ADCY2	adenylate cyclase 2	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
	ARL6IP1	ARL6 interacting reticulophagy regulator 1
	ATP2A2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Ritodrine Desflurane Sevoflurane Istaroxime	Acrokeratosis verruciformis Darier disease; Dyskeratosis follicularis
	ATP2B1	ATPase plasma membrane Ca2+ transporting 1	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases Sensory processing of sound by inner hair cells of the cochlea	Ritodrine Halothane Desflurane Sevoflurane
	ATP2C1	ATPase secretory pathway Ca2+ transporting 1	Ion transport by P-type ATPases	Enflurane Isoflurane Ritodrine Methoxyflurane Desflurane Sevoflurane Calcium	Hailey-Hailey disease; Benign familial pemphigus
	BSG	basigin (Ok blood group)	Degradation of the extracellular matrix Basigin interactions Integrin cell surface interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Aspirin ADME
	CANX	calnexin	Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate
	CAPN1	calpain 1	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
	CAPN2	calpain 2	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
	CAPNS1	calpain small subunit 1	Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	PD150606

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