ELOB - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ACSM5	acyl-CoA synthetase medium chain family member 5	Conjugation of salicylate with glycine Aspirin ADME
Novel	CAPN1	calpain 1	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Novel	CCP110	centriolar coiled-coil protein 110	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Ub-specific processing proteases AURKA Activation by TPX2 RHOV GTPase cycle
Novel	CDR2	cerebellar degeneration related protein 2
Novel	DGAT2	diacylglycerol O-acyltransferase 2	Acyl chain remodeling of DAG and TAG Triglyceride biosynthesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Omega-3-carboxylic acids Fish oil
Novel	GPS2	G protein pathway suppressor 2	PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Novel	HOXC10	homeobox C10
Novel	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Novel	STC2	stanniocalcin 2	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Novel	USP33	ubiquitin specific peptidase 33	Ub-specific processing proteases Regulation of expression of SLITs and ROBOs
	ASB11	ankyrin repeat and SOCS box containing 11	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
	ASB2	ankyrin repeat and SOCS box containing 2	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
	ASB8	ankyrin repeat and SOCS box containing 8	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
	BRD4	bromodomain containing 4	Potential therapeutics for SARS Regulation of PD-L1(CD274) transcription
	CEBPA	CCAAT enhancer binding protein alpha	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis		Acute myeloid leukemia (AML)
	CEBPE	CCAAT enhancer binding protein epsilon	Transcriptional regulation of granulopoiesis		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
	ELOA	elongin A	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
	ELOA2	elongin A2	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
	ELOA3P	elongin A3, pseudogene
	ELOC	elongin C	Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide

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