PLEKHF2 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
RPE	ribulose-5-phosphate-3-epimerase	Pentose phosphate pathway
RPRM	reprimo, TP53 dependent G2 arrest mediator homolog
RPS21	ribosomal protein S21	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
RSPO2	R-spondin 2	Regulation of FZD by ubiquitination
RTN1	reticulon 1
RTN3	reticulon 3	Synaptic adhesion-like molecules
RTN4	reticulon 4	Axonal growth inhibition (RHOA activation)
S100A1	S100 calcium binding protein A1	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand	Olopatadine
S100A13	S100 calcium binding protein A13		Olopatadine Amlexanox Calcium chloride Calcium Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
SAMD11	sterile alpha motif domain containing 11
SCYL1	SCY1 like pseudokinase 1		Grn163l
SEC14L4	SEC14 like lipid binding 4		Vitamin E
SEPTIN2	septin 2	Anchoring of the basal body to the plasma membrane
SEPTIN5	septin 5
SEPTIN6	septin 6
SETBP1	SET binding protein 1			Schinzel-Giedion midface retraction syndrome
SFN	stratifin	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
SNRNP35	small nuclear ribonucleoprotein U11/U12 subunit 35	mRNA Splicing - Minor Pathway
SOST	sclerostin	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Romosozumab	SOST related disorders, including: Sclerosteosis ; Endosteal hyperostosis, van Buchem type
SPATA24	spermatogenesis associated 24

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