|
|
MFAP1 |
microfibril associated protein 1 |
- mRNA Splicing - Major Pathway
|
|
|
|
|
MLLT6 |
MLLT6, PHD finger containing |
|
|
|
|
|
NUAK2 |
NUAK family kinase 2 |
|
|
|
|
|
PIBF1 |
progesterone immunomodulatory binding factor 1 |
|
|
|
|
|
PKP2 |
plakophilin 2 |
- Keratinization
- Formation of the cornified envelope
|
|
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|
|
|
PPP1R18 |
protein phosphatase 1 regulatory subunit 18 |
|
|
|
|
|
PRPF18 |
pre-mRNA processing factor 18 |
- mRNA Splicing - Major Pathway
|
|
|
|
|
PSMB1 |
proteasome 20S subunit beta 1 |
- Activation of NF-kappaB in B cells
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- ER-Phagosome pathway
- Cross-presentation of soluble exogenous antigens (endosomes)
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Vpu mediated degradation of CD4
- Vif-mediated degradation of APOBEC3G
- SCF(Skp2)-mediated degradation of p27/p21
- Degradation of beta-catenin by the destruction complex
- Downstream TCR signaling
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Separation of Sister Chromatids
- FCERI mediated NF-kB activation
- Autodegradation of the E3 ubiquitin ligase COP1
- Regulation of ornithine decarboxylase (ODC)
- ABC-family proteins mediated transport
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Degradation of DVL
- Hedgehog ligand biogenesis
- Hh mutants are degraded by ERAD
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'on' state
- Regulation of RAS by GAPs
- TNFR2 non-canonical NF-kB pathway
- NIK-->noncanonical NF-kB signaling
- Defective CFTR causes cystic fibrosis
- MAPK6/MAPK4 signaling
- UCH proteinases
- Ub-specific processing proteases
- Neutrophil degranulation
- Assembly of the pre-replicative complex
- Orc1 removal from chromatin
- CDK-mediated phosphorylation and removal of Cdc6
- G2/M Checkpoints
- Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
- Ubiquitin-dependent degradation of Cyclin D
- The role of GTSE1 in G2/M progression after G2 checkpoint
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Regulation of PTEN stability and activity
- Neddylation
- Regulation of expression of SLITs and ROBOs
- Interleukin-1 signaling
- Negative regulation of NOTCH4 signaling
- KEAP1-NFE2L2 pathway
- GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
- Degradation of CDH1
- Somitogenesis
- Antigen processing: Ubiquitination & Proteasome degradation
- Proteasome assembly
- Proteasome assembly
- Antigen processing: Ub, ATP-independent proteasomal degradation
- GSK3B-mediated proteasomal degradation of PD-L1(CD274)
- SPOP-mediated proteasomal degradation of PD-L1(CD274)
- AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
- Degradation of CRY and PER proteins
- Degradation of CRY and PER proteins
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
|
- Bortezomib
- (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
- Carfilzomib
|
|
|
|
RAB4A |
RAB4A, member RAS oncogene family |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Synthesis of PIPs at the plasma membrane
- TBC/RABGAPs
- RAB geranylgeranylation
- MET receptor recycling
|
|
|
|
|
RCOR3 |
REST corepressor 3 |
|
|
|
|
|
SMAD2 |
SMAD family member 2 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Signaling by Activin
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Transcriptional regulation of pluripotent stem cells
- Ub-specific processing proteases
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- Germ layer formation at gastrulation
- Formation of axial mesoderm
- Formation of definitive endoderm
- Formation of definitive endoderm
|
|
|
|
|
SMARCE1 |
SWI/SNF related BAF chromatin remodeling complex subunit E1 |
- RMTs methylate histone arginines
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
- Formation of the canonical BAF (cBAF) complex
- Formation of the polybromo-BAF (pBAF) complex
- Formation of the embryonic stem cell BAF (esBAF) complex
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
|
|
|
|
|
SMURF1 |
SMAD specific E3 ubiquitin protein ligase 1 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Asymmetric localization of PCP proteins
- Hedgehog 'on' state
- Hedgehog 'on' state
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
SNAPC5 |
small nuclear RNA activating complex polypeptide 5 |
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- RNA Polymerase III Abortive And Retractive Initiation
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
|
|
|
|
|
SNW1 |
SNW domain containing 1 |
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- NOTCH1 Intracellular Domain Regulates Transcription
- NOTCH1 Intracellular Domain Regulates Transcription
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Notch-HLH transcription pathway
- mRNA Splicing - Major Pathway
- RUNX3 regulates NOTCH signaling
- RUNX3 regulates NOTCH signaling
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH4 Intracellular Domain Regulates Transcription
- Formation of paraxial mesoderm
|
|
|
|
|
SPP1 |
secreted phosphoprotein 1 |
- Degradation of the extracellular matrix
- Signaling by PDGF
- Integrin cell surface interactions
- Integrin cell surface interactions
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- RUNX3 Regulates Immune Response and Cell Migration
- Post-translational protein phosphorylation
- Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
|
|
|
|
|
STAP1 |
signal transducing adaptor family member 1 |
|
|
|
|
|
TBC1D30 |
TBC1 domain family member 30 |
|
|
|
|
|
TCEA2 |
transcription elongation factor A2 |
|
|
|
|
|
TEPSIN |
TEPSIN adaptor related protein complex 4 accessory protein |
|
|
|