HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols CLGN and ADAM2	Name 1 calmegin	Name2 ADAM metallopeptidase domain 2	Pathway 1	Pathway 2 Interaction With Cumulus Cells And The Zona Pellucida	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols IL12A and IL12B	Name 1 interleukin 12A	Name2 interleukin 12B	Pathway 1 Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling	Pathway 2 Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Drugs 1	Drugs 2 5-Mercapto-2-Nitro-Benzoic Acid Briakinumab Ustekinumab Ustekinumab humanized SMART Anti-IL-12 Antibody Tildrakizumab Risankizumab	Diseases 1	Diseases 2 IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
Novel Novel	Symbols ADCY2 and ADCY5	Name 1 adenylate cyclase 2	Name2 adenylate cyclase 5	Pathway 1 Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Pathway 2 Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Drugs 1 Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose	Drugs 2 Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose	Diseases 1	Diseases 2
Novel Novel	Symbols RBP4 and RPE65	Name 1 retinol binding protein 4	Name2 retinoid isomerohydrolase RPE65	Pathway 1 The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport Defective visual phototransduction due to STRA6 loss of function	Pathway 2 The canonical retinoid cycle in rods (twilight vision)	Drugs 1 Tretinoin	Drugs 2 Voretigene neparvovec	Diseases 1	Diseases 2 Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
Novel Novel	Symbols TRIM54 and LINC00887	Name 1 tripartite motif containing 54	Name2 long intergenic non-protein coding RNA 887	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CALD1 and SHC1	Name 1 caldesmon 1	Name2 SHC adaptor protein 1	Pathway 1 Smooth Muscle Contraction	Pathway 2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CYB5A and CYP3A4	Name 1 cytochrome b5 type A	Name2 cytochrome P450 family 3 subfamily A member 4	Pathway 1 Vitamin C (ascorbate) metabolism	Pathway 2 Phase I - Functionalization of compounds Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs Aspirin ADME Atorvastatin ADME Prednisone ADME	Drugs 1 Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	Drugs 2 Glutathione Isoniazid Pradefovir mesylate Casopitant Cobicistat Diacerein	Diseases 1 Methemoglobinemia	Diseases 2
Novel Novel	Symbols CYB5A and UGT1A4	Name 1 cytochrome b5 type A	Name2 UDP glucuronosyltransferase family 1 member A4	Pathway 1 Vitamin C (ascorbate) metabolism	Pathway 2 Glucuronidation Heme degradation Defective UGT1A4 causes hyperbilirubinemia Aspirin ADME	Drugs 1 Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	Drugs 2	Diseases 1 Methemoglobinemia	Diseases 2
Novel Novel	Symbols TFCP2 and DNAJC5B	Name 1 transcription factor CP2	Name2 DnaJ heat shock protein family (Hsp40) member C5 beta	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols BRAP and SHCBP1L	Name 1 BRCA1 associated protein	Name2 SHC binding and spindle associated 1 like	Pathway 1 RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ENY2 and ATXN7L3B	Name 1 ENY2 transcription and export complex 2 subunit	Name2 ataxin 7 like 3B	Pathway 1 HATs acetylate histones	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NPRL3 and SESN3	Name 1 NPR3 like, GATOR1 complex subunit	Name2 sestrin 3	Pathway 1 Amino acids regulate mTORC1	Pathway 2 TP53 Regulates Metabolic Genes	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HTATIP2 and NCOA5	Name 1 HIV-1 Tat interactive protein 2	Name2 nuclear receptor coactivator 5	Pathway 1	Pathway 2	Drugs 1 Polyethylene glycol 400	Drugs 2 17alpha-Estriol	Diseases 1	Diseases 2
Novel Novel	Symbols HTATIP2 and ASF1A	Name 1 HIV-1 Tat interactive protein 2	Name2 anti-silencing function 1A histone chaperone	Pathway 1	Pathway 2 Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HTATIP2 and SH3GLB1	Name 1 HIV-1 Tat interactive protein 2	Name2 SH3 domain containing GRB2 like, endophilin B1	Pathway 1	Pathway 2	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HTATIP2 and MIEF1	Name 1 HIV-1 Tat interactive protein 2	Name2 mitochondrial elongation factor 1	Pathway 1	Pathway 2 Mitochondrial ribosome-associated quality control	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HTATIP2 and ABHD4	Name 1 HIV-1 Tat interactive protein 2	Name2 abhydrolase domain containing 4, N-acyl phospholipase B	Pathway 1	Pathway 2 Acyl chain remodelling of PE	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HTATIP2 and JPH1	Name 1 HIV-1 Tat interactive protein 2	Name2 junctophilin 1	Pathway 1	Pathway 2	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HTATIP2 and MTIF3	Name 1 HIV-1 Tat interactive protein 2	Name2 mitochondrial translational initiation factor 3	Pathway 1	Pathway 2 Mitochondrial translation initiation	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HTATIP2 and FAM209A	Name 1 HIV-1 Tat interactive protein 2	Name2 family with sequence similarity 209 member A	Pathway 1	Pathway 2	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CLGN and ADAM2	Name 1 calmegin	Name2 ADAM metallopeptidase domain 2	Pathway 1	Pathway 2 Interaction With Cumulus Cells And The Zona Pellucida	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols IL12A and IL12B	Name 1 interleukin 12A	Name2 interleukin 12B	Pathway 1 Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling	Pathway 2 Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Drugs 1	Drugs 2 5-Mercapto-2-Nitro-Benzoic Acid Briakinumab Ustekinumab Ustekinumab humanized SMART Anti-IL-12 Antibody Tildrakizumab Risankizumab	Diseases 1	Diseases 2 IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
Novel	Symbols ADCY2 and ADCY5	Name 1 adenylate cyclase 2	Name2 adenylate cyclase 5	Pathway 1 Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Pathway 2 Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Drugs 1 Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose	Drugs 2 Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose	Diseases 1	Diseases 2
Novel	Symbols RBP4 and RPE65	Name 1 retinol binding protein 4	Name2 retinoid isomerohydrolase RPE65	Pathway 1 The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport Defective visual phototransduction due to STRA6 loss of function	Pathway 2 The canonical retinoid cycle in rods (twilight vision)	Drugs 1 Tretinoin	Drugs 2 Voretigene neparvovec	Diseases 1	Diseases 2 Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
Novel	Symbols TRIM54 and LINC00887	Name 1 tripartite motif containing 54	Name2 long intergenic non-protein coding RNA 887	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CALD1 and SHC1	Name 1 caldesmon 1	Name2 SHC adaptor protein 1	Pathway 1 Smooth Muscle Contraction	Pathway 2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CYB5A and CYP3A4	Name 1 cytochrome b5 type A	Name2 cytochrome P450 family 3 subfamily A member 4	Pathway 1 Vitamin C (ascorbate) metabolism	Pathway 2 Phase I - Functionalization of compounds Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs Aspirin ADME Atorvastatin ADME Prednisone ADME	Drugs 1 Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	Drugs 2 Glutathione Isoniazid Pradefovir mesylate Casopitant Cobicistat Diacerein	Diseases 1 Methemoglobinemia	Diseases 2
Novel	Symbols CYB5A and UGT1A4	Name 1 cytochrome b5 type A	Name2 UDP glucuronosyltransferase family 1 member A4	Pathway 1 Vitamin C (ascorbate) metabolism	Pathway 2 Glucuronidation Heme degradation Defective UGT1A4 causes hyperbilirubinemia Aspirin ADME	Drugs 1 Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	Drugs 2	Diseases 1 Methemoglobinemia	Diseases 2
Novel	Symbols TFCP2 and DNAJC5B	Name 1 transcription factor CP2	Name2 DnaJ heat shock protein family (Hsp40) member C5 beta	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BRAP and SHCBP1L	Name 1 BRCA1 associated protein	Name2 SHC binding and spindle associated 1 like	Pathway 1 RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ENY2 and ATXN7L3B	Name 1 ENY2 transcription and export complex 2 subunit	Name2 ataxin 7 like 3B	Pathway 1 HATs acetylate histones	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NPRL3 and SESN3	Name 1 NPR3 like, GATOR1 complex subunit	Name2 sestrin 3	Pathway 1 Amino acids regulate mTORC1	Pathway 2 TP53 Regulates Metabolic Genes	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HTATIP2 and NCOA5	Name 1 HIV-1 Tat interactive protein 2	Name2 nuclear receptor coactivator 5	Pathway 1	Pathway 2	Drugs 1 Polyethylene glycol 400	Drugs 2 17alpha-Estriol	Diseases 1	Diseases 2
Novel	Symbols HTATIP2 and ASF1A	Name 1 HIV-1 Tat interactive protein 2	Name2 anti-silencing function 1A histone chaperone	Pathway 1	Pathway 2 Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HTATIP2 and SH3GLB1	Name 1 HIV-1 Tat interactive protein 2	Name2 SH3 domain containing GRB2 like, endophilin B1	Pathway 1	Pathway 2	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HTATIP2 and MIEF1	Name 1 HIV-1 Tat interactive protein 2	Name2 mitochondrial elongation factor 1	Pathway 1	Pathway 2 Mitochondrial ribosome-associated quality control	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HTATIP2 and ABHD4	Name 1 HIV-1 Tat interactive protein 2	Name2 abhydrolase domain containing 4, N-acyl phospholipase B	Pathway 1	Pathway 2 Acyl chain remodelling of PE	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HTATIP2 and JPH1	Name 1 HIV-1 Tat interactive protein 2	Name2 junctophilin 1	Pathway 1	Pathway 2	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HTATIP2 and MTIF3	Name 1 HIV-1 Tat interactive protein 2	Name2 mitochondrial translational initiation factor 3	Pathway 1	Pathway 2 Mitochondrial translation initiation	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HTATIP2 and FAM209A	Name 1 HIV-1 Tat interactive protein 2	Name2 family with sequence similarity 209 member A	Pathway 1	Pathway 2	Drugs 1 Polyethylene glycol 400	Drugs 2	Diseases 1	Diseases 2

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