CLGN and ADAM2

Number of citations of the paper that reports this interaction (PubMedID 11784061)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CLGN	ADAM2
Description		calmegin	ADAM metallopeptidase domain 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Cell Surface Membrane Protein-containing Complex
	Molecular Function	Calcium Ion Binding Protein Folding Chaperone Unfolded Protein Binding	Metalloendopeptidase Activity Integrin Binding Metallopeptidase Activity
	Biological Process	Protein Folding Single Fertilization Binding Of Sperm To Zona Pellucida ERAD Pathway Protein-containing Complex Assembly	Proteolysis Cell Adhesion Binding Of Sperm To Zona Pellucida Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Visual Learning Male Gonad Development Gene Expression Positive Regulation Of Gene Expression Adult Behavior
Pathways			Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		Diastolic blood pressure x sodium interaction (2df test) ( 27271309) Malaria ( 31844061) Mean arterial pressure x sodium interaction (2df test) ( 27271309) Select biomarker traits ( 17903293) Systolic blood pressure x sodium interaction (2df test) ( 27271309) Triglyceride levels in HIV infection ( 33109212)	Restless legs syndrome ( 29029846)
Interacting Genes		4 interacting genes: ADAM2 GDE1 LINC00839 XK	2 interacting genes: CD9 CLGN
Entrez ID		1047	2515
HPRD ID		03513	03322
Ensembl ID		ENSG00000153132	ENSG00000104755
Uniprot IDs		A0A140VKG2 O14967	B4DWY7 Q6P2G0 Q99965
PDB IDs
Enriched GO Terms of Interacting Partners?		Ethanolamine Metabolic Process Glycerophosphoinositol Glycerophosphodiesterase Activity Intracellular Magnesium Ion Homeostasis Regulation Of Axon Diameter N-acylethanolamine Metabolic Process Glycerophosphodiester Phosphodiesterase Activity Regulation Of Cell Projection Size Magnesium Ion Homeostasis	Sperm-egg Recognition Cell-cell Recognition Single Fertilization Cell Recognition Fertilization Myoblast Fusion Involved In Skeletal Muscle Regeneration Paranodal Junction Assembly Negative Regulation Of Platelet Aggregation Negative Regulation Of Homotypic Cell-cell Adhesion Myoblast Fusion Oligodendrocyte Development Plasma Membrane Fusion Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Platelet Aggregation Glial Cell Migration Platelet Alpha Granule Membrane Negative Regulation Of Platelet Activation Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Binding Of Sperm To Zona Pellucida Cellular Response To Lipoprotein Particle Stimulus Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Reproductive Process Negative Regulation Of Coagulation Regulation Of Macrophage Migration Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Platelet Activation Protein Folding Chaperone Receptor Internalization Clathrin-coated Endocytic Vesicle Membrane Negative Regulation Of Wound Healing Glial Cell Development Platelet Activation Regulation Of Hemostasis Regulation Of Blood Coagulation Endocytic Vesicle Membrane Extracellular Vesicle ERAD Pathway Unfolded Protein Binding Cell-cell Junction Assembly Plasma Membrane Organization Regulation Of Wound Healing Regulation Of Mononuclear Cell Migration Integrin Binding
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