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DDIT3 |
DNA damage inducible transcript 3 |
- ATF4 activates genes in response to endoplasmic reticulum stress
- ATF6 (ATF6-alpha) activates chaperone genes
- FOXO-mediated transcription of cell death genes
- FOXO-mediated transcription of cell death genes
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Response of EIF2AK1 (HRI) to heme deficiency
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DDX23 |
DEAD-box helicase 23 |
- mRNA Splicing - Major Pathway
- mRNA Splicing - Minor Pathway
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DENND1A |
DENN domain containing 1A |
- RAB GEFs exchange GTP for GDP on RABs
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DYNLL1 |
dynein light chain LC8-type 1 |
- Activation of BIM and translocation to mitochondria
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Macroautophagy
- MHC class II antigen presentation
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- Intraflagellar transport
- RHO GTPases Activate Formins
- Neutrophil degranulation
- COPI-mediated anterograde transport
- COPI-independent Golgi-to-ER retrograde traffic
- Mitotic Prometaphase
- AURKA Activation by TPX2
- HCMV Early Events
- Aggrephagy
- Aggrephagy
- EML4 and NUDC in mitotic spindle formation
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E2F4 |
E2F transcription factor 4 |
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
- G0 and Early G1
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- G1/S-Specific Transcription
- Cyclin D associated events in G1
- Cyclin A:Cdk2-associated events at S phase entry
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ECPAS |
Ecm29 proteasome adaptor and scaffold |
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EPS8 |
EGFR pathway substrate 8, signaling adaptor |
- Sensory processing of sound by inner hair cells of the cochlea
- Sensory processing of sound by outer hair cells of the cochlea
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EXOC8 |
exocyst complex component 8 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Insulin processing
- VxPx cargo-targeting to cilium
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FAM81A |
family with sequence similarity 81 member A |
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FXR2 |
FMR1 autosomal homolog 2 |
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GABARAP |
GABA type A receptor-associated protein |
- Macroautophagy
- TBC/RABGAPs
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GOLGA2 |
golgin A2 |
- Golgi Cisternae Pericentriolar Stack Reorganization
- Golgi Cisternae Pericentriolar Stack Reorganization
- COPII-mediated vesicle transport
- COPI-mediated anterograde transport
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
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GRN |
granulin precursor |
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- Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
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HAP1 |
huntingtin associated protein 1 |
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ING5 |
inhibitor of growth family member 5 |
- HATs acetylate histones
- Regulation of TP53 Activity through Acetylation
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INTS4 |
integrator complex subunit 4 |
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
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KAT5 |
lysine acetyltransferase 5 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- DNA Damage/Telomere Stress Induced Senescence
- HATs acetylate histones
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Estrogen-dependent gene expression
- Defective homologous recombination repair (HRR) due to BRCA1 loss of function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
- Impaired BRCA2 binding to RAD51
- Impaired BRCA2 binding to PALB2
- Cardiogenesis
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- Coenzyme A
- S-Acetyl-Cysteine
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KLC1 |
kinesin light chain 1 |
- MHC class II antigen presentation
- RHO GTPases activate KTN1
- COPI-dependent Golgi-to-ER retrograde traffic
- Signaling by ALK fusions and activated point mutants
- Kinesins
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KLC4 |
kinesin light chain 4 |
- MHC class II antigen presentation
- RHO GTPases activate KTN1
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
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KRT15 |
keratin 15 |
- Keratinization
- Formation of the cornified envelope
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
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