Search Results for: IRAK1

62 interactions involving IRAK1 - interleukin 1 receptor associated kinase 1 found:

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Novel Symbol Description Pathways Hide Drugs Hide Diseases Hide
IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1
IRAK2 interleukin 1 receptor associated kinase 2
  • MyD88:MAL(TIRAP) cascade initiated on plasma membrane
  • NOD1/2 Signaling Pathway
  • TAK1-dependent IKK and NF-kappa-B activation
  • activated TAK1 mediates p38 MAPK activation
  • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
  • Interleukin-1 signaling
  • IRAK2 mediated activation of TAK1 complex
  • TRAF6-mediated induction of TAK1 complex within TLR4 complex
  • SARS-CoV-1 activates/modulates innate immune responses
  • SARS-CoV-2 activates/modulates innate and adaptive immune responses
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
  • MyD88 dependent cascade initiated on endosome
  • IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
  • MyD88 cascade initiated on plasma membrane
IRAK3 interleukin 1 receptor associated kinase 3
  • MyD88:MAL(TIRAP) cascade initiated on plasma membrane
  • Interleukin-1 signaling
  • Fostamatinib
IRAK4 interleukin 1 receptor associated kinase 4
  • PIP3 activates AKT signaling
  • MyD88:MAL(TIRAP) cascade initiated on plasma membrane
  • IRAK4 deficiency (TLR5)
  • IRAK4 deficiency (TLR2/4)
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • Interleukin-1 signaling
  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
  • MyD88 dependent cascade initiated on endosome
  • MyD88 cascade initiated on plasma membrane
  • 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE
  • Fostamatinib
  • Defects of toll-like receptor signaling, including the following disease: Il-1 receptor-associated kinase 4 (IRAK-4) deficiency
IRF4 interferon regulatory factor 4
  • Interleukin-4 and Interleukin-13 signaling
  • Interferon gamma signaling
  • Interferon alpha/beta signaling
  • Nuclear events stimulated by ALK signaling in cancer
  • Regulation of MITF-M-dependent genes involved in pigmentation
IRF7 interferon regulatory factor 7
  • DEx/H-box helicases activate type I IFN and inflammatory cytokines production
  • Interferon gamma signaling
  • TICAM1-dependent activation of IRF3/IRF7
  • Interferon alpha/beta signaling
  • TRAF3-dependent IRF activation pathway
  • TRAF6 mediated IRF7 activation
  • Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
  • SARS-CoV-2 activates/modulates innate and adaptive immune responses
  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
ITGAM integrin subunit alpha M
  • Toll Like Receptor 4 (TLR4) Cascade
  • Cell surface interactions at the vascular wall
  • Integrin cell surface interactions
  • Interleukin-4 and Interleukin-13 signaling
  • Neutrophil degranulation
JUN Jun proto-oncogene, AP-1 transcription factor subunit
  • Pre-NOTCH Transcription and Translation
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • FCERI mediated MAPK activation
  • Activation of the AP-1 family of transcription factors
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • MAPK6/MAPK4 signaling
  • TP53 Regulates Transcription of DNA Repair Genes
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Regulation of PTEN gene transcription
  • Regulation of PTEN gene transcription
  • Estrogen-dependent gene expression
  • WNT5:FZD7-mediated leishmania damping
  • Signaling by ALK fusions and activated point mutants
  • Regulation of PD-L1(CD274) transcription
  • Adapalene
  • Vinblastine
  • Pseudoephedrine
  • Irbesartan
  • Arsenic trioxide
  • LGD-1550
MAP3K7 mitogen-activated protein kinase kinase kinase 7
  • Activation of NF-kappaB in B cells
  • NOD1/2 Signaling Pathway
  • Downstream TCR signaling
  • FCERI mediated NF-kB activation
  • Ca2+ pathway
  • TAK1-dependent IKK and NF-kappa-B activation
  • activated TAK1 mediates p38 MAPK activation
  • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
  • TNFR1-induced NF-kappa-B signaling pathway
  • CLEC7A (Dectin-1) signaling
  • Ub-specific processing proteases
  • TICAM1,TRAF6-dependent induction of TAK1 complex
  • Interleukin-1 signaling
  • IRAK2 mediated activation of TAK1 complex
  • TRAF6-mediated induction of TAK1 complex within TLR4 complex
  • Alpha-protein kinase 1 signaling pathway
  • SARS-CoV-2 activates/modulates innate and adaptive immune responses
  • IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MAPK14 mitogen-activated protein kinase 14
  • NOD1/2 Signaling Pathway
  • p38MAPK events
  • p38MAPK events
  • ERK/MAPK targets
  • Activation of PPARGC1A (PGC-1alpha) by phosphorylation
  • Oxidative Stress Induced Senescence
  • ADP signalling through P2Y purinoceptor 1
  • Platelet sensitization by LDL
  • VEGFA-VEGFR2 Pathway
  • activated TAK1 mediates p38 MAPK activation
  • Activation of the AP-1 family of transcription factors
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Myogenesis
  • Myogenesis
  • RHO GTPases Activate NADPH Oxidases
  • Neutrophil degranulation
  • Regulation of TP53 Activity through Phosphorylation
  • Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
  • CD163 mediating an anti-inflammatory response
  • Regulation of MITF-M-dependent genes involved in pigmentation
  • Minocycline
  • Dasatinib
  • 4-[5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine
  • N-[(3Z)-5-Tert-butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene]-N'-(4-chlorophenyl)urea
  • 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One
  • Inhibitor of P38 Kinase
  • 6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine
  • 3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine
  • 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea
  • 3-(Benzyloxy)Pyridin-2-Amine
  • l)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One
  • 4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline
  • Doramapimod
  • 2-Chlorophenol
  • 4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole
  • SB220025
  • 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE
  • Triazolopyridine
  • KC706
  • Talmapimod
  • VX-702
  • R-1487
  • 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
  • N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
  • N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide
  • Neflamapimod
  • N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide
  • 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE
  • 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE
  • N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide
  • 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE
  • 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde
  • N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide
  • N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide
  • N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide
  • PH-797804
  • 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine
  • SD-0006
  • N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA
  • N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO-
  • 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE
  • 3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide
  • 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE
  • 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA
  • 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM
  • 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE
  • N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
  • N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide
  • N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide
  • 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
  • 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE
  • [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE
  • [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE
  • 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine
  • 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE
  • 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE
  • Fostamatinib
MAPK8 mitogen-activated protein kinase 8
  • Activation of BIM and translocation to mitochondria
  • Activation of BMF and translocation to mitochondria
  • NRAGE signals death through JNK
  • NRAGE signals death through JNK
  • NRIF signals cell death from the nucleus
  • Oxidative Stress Induced Senescence
  • FCERI mediated MAPK activation
  • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
  • Activation of the AP-1 family of transcription factors
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Interleukin-38 signaling
  • WNT5:FZD7-mediated leishmania damping
  • Signaling by ALK fusions and activated point mutants
  • Tamoxifen
  • Minocycline
  • Pyrazolanthrone
  • 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
  • 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
  • N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
  • 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
  • 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
  • Halicin
MBP myelin basic protein
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination
MYD88 MYD88 innate immune signal transduction adaptor
  • ER-Phagosome pathway
  • PIP3 activates AKT signaling
  • MyD88:MAL(TIRAP) cascade initiated on plasma membrane
  • RIP-mediated NFkB activation via ZBP1
  • p75NTR recruits signalling complexes
  • p75NTR recruits signalling complexes
  • DEx/H-box helicases activate type I IFN and inflammatory cytokines production
  • MyD88 deficiency (TLR2/4)
  • MyD88 deficiency (TLR5)
  • IRAK4 deficiency (TLR5)
  • IRAK4 deficiency (TLR2/4)
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • Interleukin-1 signaling
  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
  • MyD88 dependent cascade initiated on endosome
  • MyD88 cascade initiated on plasma membrane
NLRP12 NLR family pyrin domain containing 12
  • SARS-CoV-2 activates/modulates innate and adaptive immune responses
  • Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
NTRK3 neurotrophic receptor tyrosine kinase 3
  • PIP3 activates AKT signaling
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • Receptor-type tyrosine-protein phosphatases
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • NTF3 activates NTRK3 signaling
  • NTF3 activates NTRK3 signaling
  • Signaling by NTRK3 (TRKC)
  • Activated NTRK3 signals through PLCG1
  • Activated NTRK3 signals through PLCG1
  • Activated NTRK3 signals through RAS
  • Activated NTRK3 signals through PI3K
  • Activated NTRK3 signals through PI3K
  • NTRK3 as a dependence receptor
  • Entrectinib
  • Fostamatinib
  • Larotrectinib
  • Pralsetinib
  • Neuroblastoma
OPTN optineurin
  • Regulation of PLK1 Activity at G2/M Transition
  • PINK1-PRKN Mediated Mitophagy
  • TNFR1-induced proapoptotic signaling
  • Regulation of TNFR1 signaling
  • TNFR1-induced NF-kappa-B signaling pathway
  • TBC/RABGAPs
  • TICAM1-dependent activation of IRF3/IRF7
  • Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
  • Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
  • Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
  • Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
  • Primary open angle glaucoma
PELI1 pellino E3 ubiquitin protein ligase 1
  • Regulation of necroptotic cell death
  • Interleukin-1 signaling
  • IRAK1 recruits IKK complex
  • IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
PELI2 pellino E3 ubiquitin protein ligase family member 2
  • Interleukin-1 signaling
  • IRAK1 recruits IKK complex
  • IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
PELI3 pellino E3 ubiquitin protein ligase family member 3
  • Interleukin-1 signaling
  • IRAK1 recruits IKK complex
  • IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
PPP1CC protein phosphatase 1 catalytic subunit gamma
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Triglyceride catabolism
  • Downregulation of TGF-beta receptor signaling
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • RHO GTPases Activate Formins
  • RAF activation
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
  • SHOC2 M1731 mutant abolishes MRAS complex function
  • Gain-of-function MRAS complexes activate RAF signaling
  • Maturation of hRSV A proteins
  • Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
  • 9,10-Deepithio-9,10-Didehydroacanthifolicin
  • Calyculin A
  • Motuporin

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