Cancer - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols NIF3L1 and TRAK2	Name 1 NGG1 interacting factor 3 like 1	Name2 trafficking kinesin protein 2	Pathway 1	Pathway 2 RHOT2 GTPase cycle RHOT1 GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HOXA1 and ITGB8	Name 1 homeobox A1	Name2 integrin subunit beta 8	Pathway 1 Activation of anterior HOX genes in hindbrain development during early embryogenesis	Pathway 2 Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs	Drugs 1	Drugs 2	Diseases 1 Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome	Diseases 2
Novel Novel	Symbols PRTFDC1 and GPR158	Name 1 phosphoribosyl transferase domain containing 1	Name2 G protein-coupled receptor 158	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols BLOC1S6 and SEMA6D	Name 1 biogenesis of lysosomal organelles complex 1 subunit 6	Name2 semaphorin 6D	Pathway 1 Golgi Associated Vesicle Biogenesis	Pathway 2 Other semaphorin interactions	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols DYNC1I2 and HOXD1	Name 1 dynein cytoplasmic 1 intermediate chain 2	Name2 homeobox D1	Pathway 1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Pathway 2 Activation of anterior HOX genes in hindbrain development during early embryogenesis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRIM32 and ASTN2	Name 1 tripartite motif containing 32	Name2 astrotactin 2	Pathway 1 Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Bardet-Biedl syndrome (BBS)	Diseases 2
Novel Novel	Symbols TRIM32 and NPAS3	Name 1 tripartite motif containing 32	Name2 neuronal PAS domain protein 3	Pathway 1 Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Bardet-Biedl syndrome (BBS)	Diseases 2
Novel Novel	Symbols RAB3IL1 and FADS2	Name 1 RAB3A interacting protein like 1	Name2 fatty acid desaturase 2	Pathway 1 RAB GEFs exchange GTP for GDP on RABs	Pathway 2 Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism alpha-linolenic acid (ALA) metabolism	Drugs 1	Drugs 2 alpha-Linolenic acid	Diseases 1	Diseases 2
Novel Novel	Symbols PCM1 and FGF20	Name 1 pericentriolar material 1	Name2 fibroblast growth factor 20	Pathway 1 Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Pathway 2 PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SPP1 and CD83	Name 1 secreted phosphoprotein 1	Name2 CD83 molecule	Pathway 1 Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols EEF1G and FADS1	Name 1 eukaryotic translation elongation factor 1 gamma	Name2 fatty acid desaturase 1	Pathway 1 Eukaryotic Translation Elongation Signaling by ALK fusions and activated point mutants	Pathway 2 PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism	Drugs 1	Drugs 2 alpha-Linolenic acid Icosapent	Diseases 1	Diseases 2
Novel Novel	Symbols ZNF821 and PMFBP1	Name 1 zinc finger protein 821	Name2 polyamine modulated factor 1 binding protein 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols KLHL2 and FRAS1	Name 1 kelch like family member 2	Name2 Fraser extracellular matrix complex subunit 1	Pathway 1 Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols WDR5 and ADAMTS13	Name 1 WD repeat domain 5	Name2 ADAM metallopeptidase with thrombospondin type 1 motif 13	Pathway 1 PKMTs methylate histone lysines HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation Cardiogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	Pathway 2 Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins Platelet Adhesion to exposed collagen Enhanced cleavage of VWF variant by ADAMTS13 Defective VWF cleavage by ADAMTS13 variant	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Thrombotic thrombocytopenic purpura; Moschcowitz disease; Schulman-Upshaw syndrome
Novel Novel	Symbols ABI2 and ICOS	Name 1 abl interactor 2	Name2 inducible T cell costimulator	Pathway 1 Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Pathway 2 Nuclear events stimulated by ALK signaling in cancer	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
Novel Novel	Symbols CTH and PTGFR	Name 1 cystathionine gamma-lyase	Name2 prostaglandin F receptor	Pathway 1 Degradation of cysteine and homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Pathway 2 Prostanoid ligand receptors G alpha (q) signalling events	Drugs 1 Pyridoxal phosphate Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid	Drugs 2 Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod	Diseases 1 Cystathioninuria	Diseases 2
Novel Novel	Symbols RAB2A and RP1	Name 1 RAB2A, member RAS oncogene family	Name2 RP1 axonemal microtubule associated	Pathway 1 Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRAF6 and RPP21	Name 1 TNF receptor associated factor 6	Name2 ribonuclease P subunit p21	Pathway 1 PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling MyD88 cascade initiated on plasma membrane	Pathway 2 tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RAB8A and MYO9B	Name 1 RAB8A, member RAS oncogene family	Name2 myosin IXB	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Pathway 2 Regulation of actin dynamics for phagocytic cup formation RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle FCGR3A-mediated phagocytosis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CPVL and -	Name 1 carboxypeptidase vitellogenic like	Name2 TCR gamma alternate reading frame protein	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NIF3L1 and TRAK2	Name 1 NGG1 interacting factor 3 like 1	Name2 trafficking kinesin protein 2	Pathway 1	Pathway 2 RHOT2 GTPase cycle RHOT1 GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HOXA1 and ITGB8	Name 1 homeobox A1	Name2 integrin subunit beta 8	Pathway 1 Activation of anterior HOX genes in hindbrain development during early embryogenesis	Pathway 2 Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs	Drugs 1	Drugs 2	Diseases 1 Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome	Diseases 2
Novel	Symbols PRTFDC1 and GPR158	Name 1 phosphoribosyl transferase domain containing 1	Name2 G protein-coupled receptor 158	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BLOC1S6 and SEMA6D	Name 1 biogenesis of lysosomal organelles complex 1 subunit 6	Name2 semaphorin 6D	Pathway 1 Golgi Associated Vesicle Biogenesis	Pathway 2 Other semaphorin interactions	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols DYNC1I2 and HOXD1	Name 1 dynein cytoplasmic 1 intermediate chain 2	Name2 homeobox D1	Pathway 1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Pathway 2 Activation of anterior HOX genes in hindbrain development during early embryogenesis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRIM32 and ASTN2	Name 1 tripartite motif containing 32	Name2 astrotactin 2	Pathway 1 Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Bardet-Biedl syndrome (BBS)	Diseases 2
Novel	Symbols TRIM32 and NPAS3	Name 1 tripartite motif containing 32	Name2 neuronal PAS domain protein 3	Pathway 1 Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Bardet-Biedl syndrome (BBS)	Diseases 2
Novel	Symbols RAB3IL1 and FADS2	Name 1 RAB3A interacting protein like 1	Name2 fatty acid desaturase 2	Pathway 1 RAB GEFs exchange GTP for GDP on RABs	Pathway 2 Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism alpha-linolenic acid (ALA) metabolism	Drugs 1	Drugs 2 alpha-Linolenic acid	Diseases 1	Diseases 2
Novel	Symbols PCM1 and FGF20	Name 1 pericentriolar material 1	Name2 fibroblast growth factor 20	Pathway 1 Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Pathway 2 PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SPP1 and CD83	Name 1 secreted phosphoprotein 1	Name2 CD83 molecule	Pathway 1 Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols EEF1G and FADS1	Name 1 eukaryotic translation elongation factor 1 gamma	Name2 fatty acid desaturase 1	Pathway 1 Eukaryotic Translation Elongation Signaling by ALK fusions and activated point mutants	Pathway 2 PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism	Drugs 1	Drugs 2 alpha-Linolenic acid Icosapent	Diseases 1	Diseases 2
Novel	Symbols ZNF821 and PMFBP1	Name 1 zinc finger protein 821	Name2 polyamine modulated factor 1 binding protein 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols KLHL2 and FRAS1	Name 1 kelch like family member 2	Name2 Fraser extracellular matrix complex subunit 1	Pathway 1 Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols WDR5 and ADAMTS13	Name 1 WD repeat domain 5	Name2 ADAM metallopeptidase with thrombospondin type 1 motif 13	Pathway 1 PKMTs methylate histone lysines HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation Cardiogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	Pathway 2 Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins Platelet Adhesion to exposed collagen Enhanced cleavage of VWF variant by ADAMTS13 Defective VWF cleavage by ADAMTS13 variant	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Thrombotic thrombocytopenic purpura; Moschcowitz disease; Schulman-Upshaw syndrome
Novel	Symbols ABI2 and ICOS	Name 1 abl interactor 2	Name2 inducible T cell costimulator	Pathway 1 Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Pathway 2 Nuclear events stimulated by ALK signaling in cancer	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
Novel	Symbols CTH and PTGFR	Name 1 cystathionine gamma-lyase	Name2 prostaglandin F receptor	Pathway 1 Degradation of cysteine and homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Pathway 2 Prostanoid ligand receptors G alpha (q) signalling events	Drugs 1 Pyridoxal phosphate Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid	Drugs 2 Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod	Diseases 1 Cystathioninuria	Diseases 2
Novel	Symbols RAB2A and RP1	Name 1 RAB2A, member RAS oncogene family	Name2 RP1 axonemal microtubule associated	Pathway 1 Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRAF6 and RPP21	Name 1 TNF receptor associated factor 6	Name2 ribonuclease P subunit p21	Pathway 1 PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling MyD88 cascade initiated on plasma membrane	Pathway 2 tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RAB8A and MYO9B	Name 1 RAB8A, member RAS oncogene family	Name2 myosin IXB	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Pathway 2 Regulation of actin dynamics for phagocytic cup formation RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle FCGR3A-mediated phagocytosis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CPVL and -	Name 1 carboxypeptidase vitellogenic like	Name2 TCR gamma alternate reading frame protein	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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