CTH and PTGFR

		CTH	PTGFR
Description		cystathionine gamma-lyase	prostaglandin F receptor
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Extracellular Region Cytoplasm Plasma Membrane Membrane
	Molecular Function	Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding L-cystine L-cysteine-lyase (deaminating) Homocysteine Desulfhydrase Activity L-cysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity	G Protein-coupled Receptor Activity Prostaglandin F Receptor Activity
	Biological Process	Cysteine Metabolic Process Lipid Metabolic Process Amino Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Sulfhydration Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Apoptotic Signaling Pathway	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus
Pathways		Degradation of cysteine and homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Prostanoid ligand receptors G alpha (q) signalling events
Drugs		Pyridoxal phosphate Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid	Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod
Diseases		Cystathioninuria
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Brain volume in infants (grey matter) ( 28763065) Declining hemoglobin trajectory in blood donors ( 33491795) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Seasonality and depression ( 30217971)	Bipolar disorder ( 22182935) Depression in multiple sclerosis (post-diagnosis) ( 33296963) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)
Interacting Genes		4 interacting genes: GUCD1 NTAQ1 RECK SDCBP2	5 interacting genes: AGTR1 PTGDS PTGER1 PTGER2 PTGES2
Entrez ID		1491	5737
HPRD ID		09633	08988
Ensembl ID		ENSG00000116761	ENSG00000122420
Uniprot IDs		P32929	P43088
PDB IDs		2NMP 3COG 3ELP 5EIG 5TSU 5TT2 6NBA 6OVG	8IQ4 8IQ6 8IUK 8IUL 8IUM 8XJK 8XJL 8XJM
Enriched GO Terms of Interacting Partners?		Prostaglandin F Receptor Activity Protein-N-terminal Glutamine Amidohydrolase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Establishment Of Blood-brain Barrier	Prostaglandin E Receptor Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Type I Receptor Activity L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity Homocysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity Cystathionine Gamma-lyase Activity Carboxylic Acid Biosynthetic Process Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Response To Prostaglandin E Fucose-1-phosphate Guanylyltransferase Activity Efferent Axon Development In A Lateral Line Nerve Medullary Reticular Formation Development Retrotrapezoid Nucleus Neuron Differentiation Ribosomal Large Subunit Biogenesis Noc2p-Noc3p Complex Noc1p-Noc2p Complex G Protein-coupled Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Cysteine Biosynthetic Process Via Cystathionine Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Parasympathetic Nervous System Development Cellular Response To Carbon Dioxide Negative Regulation Of Type B Pancreatic Cell Proliferation Response To Carbon Dioxide Protein Phosphatase Binding IkappaB Kinase Activity 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Small Molecule Biosynthetic Process Cysteine Biosynthetic Process Transsulfuration
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