HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols BLMH and CYP2C8	Name 1 bleomycin hydrolase	Name2 cytochrome P450 family 2 subfamily C member 8	Pathway 1 Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME	Drugs 1	Drugs 2 Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE	Diseases 1	Diseases 2
Novel Novel	Symbols CFTR and DOCK10	Name 1 CF transmembrane conductance regulator	Name2 dedicator of cytokinesis 10	Pathway 1 ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells	Pathway 2 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Factors involved in megakaryocyte development and platelet production	Drugs 1 ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Drugs 2	Diseases 1 Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens	Diseases 2
Novel Novel	Symbols CFTR and VPS4B	Name 1 CF transmembrane conductance regulator	Name2 vacuolar protein sorting 4 homolog B	Pathway 1 ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells	Pathway 2 Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)	Drugs 1 ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Drugs 2	Diseases 1 Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens	Diseases 2
Novel Novel	Symbols CFTR and SMIM21	Name 1 CF transmembrane conductance regulator	Name2 small integral membrane protein 21	Pathway 1 ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells	Pathway 2	Drugs 1 ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Drugs 2	Diseases 1 Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens	Diseases 2
Novel Novel	Symbols CFTR and HTATIP2	Name 1 CF transmembrane conductance regulator	Name2 HIV-1 Tat interactive protein 2	Pathway 1 ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells	Pathway 2	Drugs 1 ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Drugs 2 Polyethylene glycol 400	Diseases 1 Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens	Diseases 2
Novel Novel	Symbols MCM3 and SUPT16H	Name 1 minichromosome maintenance complex component 3	Name2 SPT16 homolog, facilitates chromatin remodeling subunit	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PRKAB2 and IL37	Name 1 protein kinase AMP-activated non-catalytic subunit beta 2	Name2 interleukin 37	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Pathway 2 Interleukin-37 signaling Interleukin-18 signaling	Drugs 1 Adenosine phosphate Acetylsalicylic acid Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PRKAB2 and ZFP90	Name 1 protein kinase AMP-activated non-catalytic subunit beta 2	Name2 ZFP90 zinc finger protein	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Pathway 2 Generic Transcription Pathway	Drugs 1 Adenosine phosphate Acetylsalicylic acid Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RNF4 and AIM2	Name 1 ring finger protein 4	Name2 absent in melanoma 2	Pathway 1 Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Cytosolic sensors of pathogen-associated DNA The AIM2 inflammasome The AIM2 inflammasome	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CDC5L and EMID1	Name 1 cell division cycle 5 like	Name2 EMI domain containing 1	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2 O-linked glycosylation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRIP6 and NUP210	Name 1 thyroid hormone receptor interactor 6	Name2 nucleoporin 210	Pathway 1	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TLR4 and RNF216	Name 1 toll like receptor 4	Name2 ring finger protein 216	Pathway 1 ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex Heme signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions	Pathway 2 Negative regulators of DDX58/IFIH1 signaling	Drugs 1 Cyclobenzaprine Naloxone (R)-3-hydroxytetradecanoic acid Lauric acid Eritoran Golotimod E5531 Myristic acid Papain Mifamurtide	Drugs 2	Diseases 1 Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Diseases 2
Novel Novel	Symbols SMAD3 and XPO6	Name 1 SMAD family member 3	Name2 exportin 6	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CCNT2 and HEXIM1	Name 1 cyclin T2	Name2 HEXIM P-TEFb complex subunit 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ZBTB17 and ZBTB7C	Name 1 zinc finger and BTB domain containing 17	Name2 zinc finger and BTB domain containing 7C	Pathway 1 XBP1(S) activates chaperone genes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TOM1 and SSBP2	Name 1 target of myb1 membrane trafficking protein	Name2 single stranded DNA binding protein 2	Pathway 1 Neutrophil degranulation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HDAC2 and RCOR1	Name 1 histone deacetylase 2	Name2 REST corepressor 1	Pathway 1 p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Pathway 2 HDACs deacetylate histones Regulation of PTEN gene transcription Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production	Drugs 1 Pravastatin Lovastatin Theophylline Valproic acid Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Decitabine Oxtriphylline Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Tixocortol Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FEZ1 and HTATSF1	Name 1 fasciculation and elongation protein zeta 1	Name2 HIV-1 Tat specific factor 1	Pathway 1	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HSPB1 and NVL	Name 1 heat shock protein family B (small) member 1	Name2 nuclear VCP like	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel Novel	Symbols HSPB1 and PTPN3	Name 1 heat shock protein family B (small) member 1	Name2 protein tyrosine phosphatase non-receptor type 3	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 EGFR downregulation Negative regulation of MAPK pathway	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel	Symbols BLMH and CYP2C8	Name 1 bleomycin hydrolase	Name2 cytochrome P450 family 2 subfamily C member 8	Pathway 1 Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME	Drugs 1	Drugs 2 Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE	Diseases 1	Diseases 2
Novel	Symbols CFTR and DOCK10	Name 1 CF transmembrane conductance regulator	Name2 dedicator of cytokinesis 10	Pathway 1 ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells	Pathway 2 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Factors involved in megakaryocyte development and platelet production	Drugs 1 ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Drugs 2	Diseases 1 Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens	Diseases 2
Novel	Symbols CFTR and VPS4B	Name 1 CF transmembrane conductance regulator	Name2 vacuolar protein sorting 4 homolog B	Pathway 1 ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells	Pathway 2 Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)	Drugs 1 ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Drugs 2	Diseases 1 Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens	Diseases 2
Novel	Symbols CFTR and SMIM21	Name 1 CF transmembrane conductance regulator	Name2 small integral membrane protein 21	Pathway 1 ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells	Pathway 2	Drugs 1 ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Drugs 2	Diseases 1 Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens	Diseases 2
Novel	Symbols CFTR and HTATIP2	Name 1 CF transmembrane conductance regulator	Name2 HIV-1 Tat interactive protein 2	Pathway 1 ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells	Pathway 2	Drugs 1 ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Drugs 2 Polyethylene glycol 400	Diseases 1 Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens	Diseases 2
Novel	Symbols MCM3 and SUPT16H	Name 1 minichromosome maintenance complex component 3	Name2 SPT16 homolog, facilitates chromatin remodeling subunit	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PRKAB2 and IL37	Name 1 protein kinase AMP-activated non-catalytic subunit beta 2	Name2 interleukin 37	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Pathway 2 Interleukin-37 signaling Interleukin-18 signaling	Drugs 1 Adenosine phosphate Acetylsalicylic acid Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PRKAB2 and ZFP90	Name 1 protein kinase AMP-activated non-catalytic subunit beta 2	Name2 ZFP90 zinc finger protein	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Pathway 2 Generic Transcription Pathway	Drugs 1 Adenosine phosphate Acetylsalicylic acid Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RNF4 and AIM2	Name 1 ring finger protein 4	Name2 absent in melanoma 2	Pathway 1 Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Cytosolic sensors of pathogen-associated DNA The AIM2 inflammasome The AIM2 inflammasome	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CDC5L and EMID1	Name 1 cell division cycle 5 like	Name2 EMI domain containing 1	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2 O-linked glycosylation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRIP6 and NUP210	Name 1 thyroid hormone receptor interactor 6	Name2 nucleoporin 210	Pathway 1	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TLR4 and RNF216	Name 1 toll like receptor 4	Name2 ring finger protein 216	Pathway 1 ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex Heme signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions	Pathway 2 Negative regulators of DDX58/IFIH1 signaling	Drugs 1 Cyclobenzaprine Naloxone (R)-3-hydroxytetradecanoic acid Lauric acid Eritoran Golotimod E5531 Myristic acid Papain Mifamurtide	Drugs 2	Diseases 1 Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Diseases 2
Novel	Symbols SMAD3 and XPO6	Name 1 SMAD family member 3	Name2 exportin 6	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CCNT2 and HEXIM1	Name 1 cyclin T2	Name2 HEXIM P-TEFb complex subunit 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ZBTB17 and ZBTB7C	Name 1 zinc finger and BTB domain containing 17	Name2 zinc finger and BTB domain containing 7C	Pathway 1 XBP1(S) activates chaperone genes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TOM1 and SSBP2	Name 1 target of myb1 membrane trafficking protein	Name2 single stranded DNA binding protein 2	Pathway 1 Neutrophil degranulation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HDAC2 and RCOR1	Name 1 histone deacetylase 2	Name2 REST corepressor 1	Pathway 1 p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Pathway 2 HDACs deacetylate histones Regulation of PTEN gene transcription Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production	Drugs 1 Pravastatin Lovastatin Theophylline Valproic acid Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Decitabine Oxtriphylline Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Tixocortol Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FEZ1 and HTATSF1	Name 1 fasciculation and elongation protein zeta 1	Name2 HIV-1 Tat specific factor 1	Pathway 1	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HSPB1 and NVL	Name 1 heat shock protein family B (small) member 1	Name2 nuclear VCP like	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel	Symbols HSPB1 and PTPN3	Name 1 heat shock protein family B (small) member 1	Name2 protein tyrosine phosphatase non-receptor type 3	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 EGFR downregulation Negative regulation of MAPK pathway	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2

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