HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols NFE2L2 and NFE2L3	Name 1 NFE2 like bZIP transcription factor 2	Name2 NFE2 like bZIP transcription factor 3	Pathway 1 Neddylation Potential therapeutics for SARS Regulation of HMOX1 expression and activity Heme signaling KEAP1-NFE2L2 pathway KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 NFE2L2 regulating TCA cycle genes NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Regulation of PD-L1(CD274) transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NCK1 and NCKAP5	Name 1 NCK adaptor protein 1	Name2 NCK associated protein 5	Pathway 1 Downstream signal transduction Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Nephrin family interactions DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHOU GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Potential therapeutics for SARS PKR-mediated signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols KPNA4 and HJURP	Name 1 karyopherin subunit alpha 4	Name2 Holliday junction recognition protein	Pathway 1 ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Pathway 2 Deposition of new CENPA-containing nucleosomes at the centromere Cyclin A/B1/B2 associated events during G2/M transition	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AP2M1 and MAB21L3	Name 1 adaptor related protein complex 2 subunit mu 1	Name2 mab-21 like 3	Pathway 1 Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PSEN2 and EVI5L	Name 1 presenilin 2	Name2 ecotropic viral integration site 5 like	Pathway 1 Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Alzheimer's disease (AD)	Diseases 2
Novel Novel	Symbols FXR1 and CCBE1	Name 1 FMR1 autosomal homolog 1	Name2 collagen and calcium binding EGF domains 1	Pathway 1 Signaling by BRAF and RAF1 fusions	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HAP1 and ZNF648	Name 1 huntingtin associated protein 1	Name2 zinc finger protein 648	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RAN and RANBP1	Name 1 RAN, member RAS oncogene family	Name2 RAN binding protein 1	Pathway 1 Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation	Pathway 2 Rev-mediated nuclear export of HIV RNA	Drugs 1 Guanosine-5'-Diphosphate	Drugs 2 Copper Phenethyl Isothiocyanate	Diseases 1	Diseases 2
Novel Novel	Symbols RAN and SSRP1	Name 1 RAN, member RAS oncogene family	Name2 structure specific recognition protein 1	Pathway 1 Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation	Pathway 2 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Drugs 1 Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols YWHAZ and RAP1GAP2	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Name2 RAP1 GTPase activating protein 2	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Rap1 signalling	Drugs 1 Phenethyl Isothiocyanate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TSG101 and GLIS3	Name 1 tumor susceptibility 101	Name2 GLIS family zinc finger 3	Pathway 1 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRAF1 and SLC25A48	Name 1 TNF receptor associated factor 1	Name2 solute carrier family 25 member 48	Pathway 1 Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRAF2 and ELOA2	Name 1 TNF receptor associated factor 2	Name2 elongin A2	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols IL16 and KIF16B	Name 1 interleukin 16	Name2 kinesin family member 16B	Pathway 1 Other interleukin signaling	Pathway 2 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RAC1 and SH3RF3	Name 1 Rac family small GTPase 1	Name2 SH3 domain containing ring finger 3	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Azathioprine ADME Factors involved in megakaryocyte development and platelet production	Pathway 2	Drugs 1 Dextromethorphan Azathioprine Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RAC1 and SNX31	Name 1 Rac family small GTPase 1	Name2 sorting nexin 31	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Azathioprine ADME Factors involved in megakaryocyte development and platelet production	Pathway 2	Drugs 1 Dextromethorphan Azathioprine Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CRX and BANF1	Name 1 cone-rod homeobox	Name2 barrier to autointegration nuclear assembly factor 1	Pathway 1	Pathway 2 Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation	Drugs 1	Drugs 2	Diseases 1 Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Diseases 2
Novel Novel	Symbols NEDD4 and CUEDC1	Name 1 NEDD4 E3 ubiquitin protein ligase	Name2 CUE domain containing 1	Pathway 1 ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NEDD4 and PRKG2	Name 1 NEDD4 E3 ubiquitin protein ligase	Name2 protein kinase cGMP-dependent 2	Pathway 1 ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing	Drugs 1	Drugs 2 Fostamatinib	Diseases 1	Diseases 2
Novel Novel	Symbols DNM2 and PCNT	Name 1 dynamin 2	Name2 pericentrin	Pathway 1 Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription Degradation of CDH1	Pathway 2 Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Drugs 1	Drugs 2	Diseases 1 Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Diseases 2 Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
Novel	Symbols NFE2L2 and NFE2L3	Name 1 NFE2 like bZIP transcription factor 2	Name2 NFE2 like bZIP transcription factor 3	Pathway 1 Neddylation Potential therapeutics for SARS Regulation of HMOX1 expression and activity Heme signaling KEAP1-NFE2L2 pathway KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 NFE2L2 regulating TCA cycle genes NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Regulation of PD-L1(CD274) transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NCK1 and NCKAP5	Name 1 NCK adaptor protein 1	Name2 NCK associated protein 5	Pathway 1 Downstream signal transduction Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Nephrin family interactions DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHOU GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Potential therapeutics for SARS PKR-mediated signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols KPNA4 and HJURP	Name 1 karyopherin subunit alpha 4	Name2 Holliday junction recognition protein	Pathway 1 ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Pathway 2 Deposition of new CENPA-containing nucleosomes at the centromere Cyclin A/B1/B2 associated events during G2/M transition	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AP2M1 and MAB21L3	Name 1 adaptor related protein complex 2 subunit mu 1	Name2 mab-21 like 3	Pathway 1 Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PSEN2 and EVI5L	Name 1 presenilin 2	Name2 ecotropic viral integration site 5 like	Pathway 1 Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Alzheimer's disease (AD)	Diseases 2
Novel	Symbols FXR1 and CCBE1	Name 1 FMR1 autosomal homolog 1	Name2 collagen and calcium binding EGF domains 1	Pathway 1 Signaling by BRAF and RAF1 fusions	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HAP1 and ZNF648	Name 1 huntingtin associated protein 1	Name2 zinc finger protein 648	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RAN and RANBP1	Name 1 RAN, member RAS oncogene family	Name2 RAN binding protein 1	Pathway 1 Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation	Pathway 2 Rev-mediated nuclear export of HIV RNA	Drugs 1 Guanosine-5'-Diphosphate	Drugs 2 Copper Phenethyl Isothiocyanate	Diseases 1	Diseases 2
Novel	Symbols RAN and SSRP1	Name 1 RAN, member RAS oncogene family	Name2 structure specific recognition protein 1	Pathway 1 Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation	Pathway 2 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Drugs 1 Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols YWHAZ and RAP1GAP2	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Name2 RAP1 GTPase activating protein 2	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Rap1 signalling	Drugs 1 Phenethyl Isothiocyanate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TSG101 and GLIS3	Name 1 tumor susceptibility 101	Name2 GLIS family zinc finger 3	Pathway 1 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRAF1 and SLC25A48	Name 1 TNF receptor associated factor 1	Name2 solute carrier family 25 member 48	Pathway 1 Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRAF2 and ELOA2	Name 1 TNF receptor associated factor 2	Name2 elongin A2	Pathway 1 Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Pathway 2 Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols IL16 and KIF16B	Name 1 interleukin 16	Name2 kinesin family member 16B	Pathway 1 Other interleukin signaling	Pathway 2 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RAC1 and SH3RF3	Name 1 Rac family small GTPase 1	Name2 SH3 domain containing ring finger 3	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Azathioprine ADME Factors involved in megakaryocyte development and platelet production	Pathway 2	Drugs 1 Dextromethorphan Azathioprine Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RAC1 and SNX31	Name 1 Rac family small GTPase 1	Name2 sorting nexin 31	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Azathioprine ADME Factors involved in megakaryocyte development and platelet production	Pathway 2	Drugs 1 Dextromethorphan Azathioprine Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CRX and BANF1	Name 1 cone-rod homeobox	Name2 barrier to autointegration nuclear assembly factor 1	Pathway 1	Pathway 2 Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation	Drugs 1	Drugs 2	Diseases 1 Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Diseases 2
Novel	Symbols NEDD4 and CUEDC1	Name 1 NEDD4 E3 ubiquitin protein ligase	Name2 CUE domain containing 1	Pathway 1 ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NEDD4 and PRKG2	Name 1 NEDD4 E3 ubiquitin protein ligase	Name2 protein kinase cGMP-dependent 2	Pathway 1 ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing	Drugs 1	Drugs 2 Fostamatinib	Diseases 1	Diseases 2
Novel	Symbols DNM2 and PCNT	Name 1 dynamin 2	Name2 pericentrin	Pathway 1 Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription Degradation of CDH1	Pathway 2 Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Drugs 1	Drugs 2	Diseases 1 Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Diseases 2 Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome

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