KYNU and MYOZ3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KYNU	MYOZ3
Name		kynureninase	myozenin 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Cytoplasm Actin Cytoskeleton Z Disc
	Molecular Function	Protein Binding Hydrolase Activity Pyridoxal Phosphate Binding Kynureninase Activity Protein Homodimerization Activity	Actin Binding Protein Binding Telethonin Binding FATZ Binding
	Biological Process	L-tryptophan Catabolic Process Nucleoside Phosphate Metabolic Process NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process L-tryptophan Catabolic Process To Kynurenine Quinolinate Biosynthetic Process Response To Type II Interferon 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Response To Vitamin B6 Anthranilate Metabolic Process Purine-containing Compound Metabolic Process L-kynurenine Catabolic Process	None
Pathways		Tryptophan catabolism	None
Drugs		Pyridoxal phosphate Alanine m-Hydroxyhippuric acid	None
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma ( 32296059 ) Asthma and eczema ( 34155719 ) Blood protein levels ( 30072576 ) Cataracts ( 34127677 ) Empathy quotient ( 29527006 ) Glomerular filtration rate in chronic kidney disease ( 26420894 ) Neurological blood protein biomarker levels ( 31320639 ) Platelet count ( 32888494 ) Response to SSRI (symptom remission) ( 29160301 ) Toenail selenium levels ( 25343990 )	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 )
Interacting Genes		9 interacting genes: CDC42 CT55 CTBP2 FAM86C1P LMO4 MCCD1 MYOZ3 PIP4K2B RASSF3	71 interacting genes: ABI2 ACTN1 ACTN2 AKIRIN2 ASPG ATOSB ATXN1L BAG4 BCAS2 C10orf55 CCDC57 CIMIP2B CREM CRLF3 DAZAP2 DMRT3 EFS ENKD1 EXOC8 FAM168B FHL3 FHL5 FLNC GCM2 GOLGA6A GOLGA6L9 HSF2BP KANK2 KRT34 KRT36 KRT75 KRTAP19-5 KRTAP19-6 KRTAP6-1 KRTAP7-1 KRTAP8-1 KYNU LDB3 LENG8 LMO2 LMO3 LMO4 LONRF1 MAPK6 MORN3 MRPL38 MYO15B NEK6 NUTF2 PDLIM3 PITX1 PM20D2 PPP3CA PPP3CB PRDM6 PSMB4 PTK6 RINT1 RNF125 RUSC1 SPMIP5 TBX15 TCAP TEKT4 TRAPPC6A TSC1 TSSK3 UFSP1 YPEL3 ZNF620 ZNF688
Entrez ID		8942	91977
HPRD ID		08940	17624
Ensembl ID		ENSG00000115919	ENSG00000164591
Uniprot IDs		Q16719 Q53SX6	Q8TDC0
PDB IDs		2HZP 3E9K 7S3V	Not available
GO Terms Enriched among Interactors		None	Z Disc Intermediate Filament Muscle Cell Development Cytoskeletal Protein Binding Cytoskeleton Organization Protein Binding Titin Z Domain Binding Sarcomere Organization Pseudopodium FATZ Binding Calmodulin-dependent Protein Phosphatase Activity Striated Muscle Cell Development Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Organelle Organization Actin Filament Stress Fiber Cell Projection Protein Serine/threonine Phosphatase Complex