TNFSF15

Name	TNF superfamily member 15
Structure
Novel Interactors	7 novel interactors: DELEC1 FKBP15 OAT PTBP3 SLC46A2 SRSF11 TMEM126A
Interactors	2 interactors: TNFRSF25 TNFRSF6B
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways	TNFs bind their physiological receptors
Diseases	Crohn's disease
GWAS	Asthma ( 32296059 ) Asthma (childhood onset) ( 34022066 ) Behcet's disease ( 33393726 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 18587394 21102463 32581322 30500874 23266558 26891255 ) Inflammatory bowel disease ( 18758464 27569725 23128233 ) Leprosy ( 25642632 20018961 ) Metabolite levels ( 23823483 ) Pediatric autoimmune diseases ( 26301688 ) Primary biliary cholangitis ( 28062665 28425483 23000144 30643196 ) Ulcerative colitis ( 21297633 20848476 ) Ulcerative colitis or Crohn's disease ( 21699788 )
Entrez ID	9966
HPRD ID	04956
Ensembl ID	ENSG00000181634
Uniprot IDs	A0A0U5JA19 O95150
PDB IDs	2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
GO Terms Enriched among Interactors ?	L-arginine Catabolic Process To L-glutamate Ornithine Aminotransferase Activity L-arginine Catabolic Process To Proline Via Ornithine