ITM2B

Name	integral membrane protein 2B
Structure
Interactors	7 interactors: APP BCL2 CREB3 KASH5 LMNA NAALADL2 SYNE4
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Golgi-associated Vesicle Membrane Organelle Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protein Binding ATP Binding
	Biological Process	Nervous System Development Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways	Amyloid fiber formation
GWAS	Severe insulin-deficient type 2 diabetes ( 34737425 )
Entrez ID	9445
HPRD ID	04878
Ensembl ID	ENSG00000136156
Uniprot IDs	A0A384MDP7 Q9Y287
PDB IDs	8RNU
GO Terms Enriched among Interactors ?	Regulation Of Apoptotic Signaling Pathway Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Neuron Maturation Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Apoptotic Signaling Pathway Nuclear Envelope Nuclear Outer Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Cell Migration Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Development Regulation Of Metal Ion Transport Regulation Of Cell Motility Identical Protein Binding Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cellular PH Reduction Striated Muscle Cell Development Positive Regulation Of Deacetylase Activity Regulation Of Monoatomic Ion Transport Regulation Of Locomotion Chromosome Localization Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Positive Regulation Of Protein Import Supramolecular Fiber Organization Muscle Cell Development CD8-positive, Alpha-beta T Cell Lineage Commitment BAD-BCL-2 Complex Channel Inhibitor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Meiotic Spindle Pole PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production