NOG

Name	noggin
Structure
Interactors	4 interactors: BMP2 BMP4 BMP5 BMP7
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Presynapse
	Molecular Function	Protein Binding Growth Factor Binding Protein Homodimerization Activity Receptor Ligand Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Urogenital System Development Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Epithelial To Mesenchymal Transition Neural Plate Morphogenesis Neural Tube Closure Membranous Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Smoothened Signaling Pathway Pattern Specification Process Nervous System Development Axon Guidance Central Nervous System Development Brain Development Endoderm Development Mesoderm Development Motor Neuron Axon Guidance Cell Population Proliferation Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Spinal Cord Development Cell Differentiation In Hindbrain Neural Tube Development Pituitary Gland Development Neural Plate Anterior/posterior Regionalization Cell Differentiation Negative Regulation Of Cell Migration BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Somatic Stem Cell Population Maintenance Exploration Behavior Nodal Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Middle Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neuronal Synaptic Plasticity Axial Mesoderm Development Embryonic Organ Morphogenesis Notochord Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Development Negative Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Atrial Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Limb Development Embryonic Skeletal Joint Morphogenesis Long-term Synaptic Potentiation Face Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Lung Morphogenesis Prostatic Bud Formation Ureteric Bud Formation Negative Regulation Of Cartilage Development Somite Development Heart Trabecula Morphogenesis Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Glomerulus Development Presynaptic Modulation Of Chemical Synaptic Transmission Cranial Skeletal System Development Short-term Synaptic Potentiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways	Signaling by BMP Formation of paraxial mesoderm
Diseases	Stapes ankylosis with broad thumb and toes Other brachydactylies, including: Proximal symphalangism; Multiple synostosis syndrome Tarsal-carpal coalition syndrome Brachydactyly, including: type A; type B; type D; type E
GWAS	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Celiac disease ( 23936387 ) Height ( 18391951 20881960 31562340 ) Metabolite levels ( 23823483 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Orofacial clefts ( 20023658 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Waist circumference adjusted for body mass index ( 34021172 )
Entrez ID	9241
HPRD ID	04291
Ensembl ID	ENSG00000183691
Uniprot IDs	Q13253
PDB IDs	1M4U 7AG0
GO Terms Enriched among Interactors ?	BMP Receptor Binding Positive Regulation Of SMAD Protein Signal Transduction Ameloblast Differentiation Regulation Of SMAD Protein Signal Transduction BMP Signaling Pathway Endocardial Cushion Formation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cartilage Development Regulation Of Epithelial To Mesenchymal Transition Ossification Growth Factor Activity Muscle Tissue Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Skeletal System Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Animal Organ Formation Cellular Response To BMP Stimulus Cytokine Activity Positive Regulation Of Bone Mineralization Heart Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neural Fold Elevation Formation Morphogenesis Of An Epithelium Mesenchyme Development Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Aldosterone Biosynthetic Process Cardiac Jelly Development Negative Regulation Of Cortisol Biosynthetic Process Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Epithelial Cell Differentiation Cardiac Muscle Tissue Development Negative Regulation Of Prostatic Bud Formation Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Allantois Development Protein Serine/threonine Kinase Activator Activity Positive Regulation Of Osteoblast Differentiation Pattern Specification Process Cardiac Septum Morphogenesis Tissue Morphogenesis Regulation Of Bone Mineralization Regulation Of Animal Organ Morphogenesis Negative Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Epithelial To Mesenchymal Transition Telencephalon Regionalization