NEXN

Name	nexilin F-actin binding protein
Structure	No pdb structure
Interactors	11 interactors: ACTA1 CALM1 FAM107A FXR2 HMGB1 HMGB2 HSPB1 SIRPA TRIM15 ZNF250 ZSCAN22
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Axon Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Regulation Of Cell Migration Regulation Of Cytoskeleton Organization Dendrite Self-avoidance
GWAS	FEV1 ( 30804560 ) Lung cancer in never smokers ( 28604730 ) Lung function (FEV1/FVC) ( 30804560 ) Peak expiratory flow ( 30804560 )
Entrez ID	91624
HPRD ID	11388
Ensembl ID	ENSG00000162614
Uniprot IDs	B4DDI0 Q0ZGT2
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of Type I Interferon Production Supercoiled DNA Binding Regulation Of Interferon-beta Production DNA Geometric Change DNA Topological Change RAGE Receptor Binding Positive Regulation Of Type I Interferon Production Regulation Of Interleukin-1 Beta Production Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Production DNA Binding, Bending Four-way Junction DNA Binding DNA Conformation Change V(D)J Recombination Regulation Of Macromolecule Metabolic Process Negative Regulation Of Phagocytosis Regulation Of Cytokine Production Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Synaptic Plasticity Regulation Of Cell Communication Regulation Of Signaling Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cytokine Production Chemoattractant Activity Regulation Of Tumor Necrosis Factor Production Condensed Chromosome Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Interferon-beta Production Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Somatic Cell DNA Recombination Positive Chemotaxis Sarcomere Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Beta Production Transcription Coactivator Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Process Damaged DNA Binding Positive Regulation Of Innate Immune Response Negative Regulation Of Endocytosis Cellular Response To Type II Interferon Positive Regulation Of Interleukin-1 Production